Low lead levels stunt neuronal growth in a reversible manner

Hollis T. Cline; Sonia Witte; Keith W. Jones

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Low lead levels stunt neuronal growth in a reversible manner

机译：低铅水平以可逆的方式阻碍神经元生长

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The developing brain is particularly suscep- tible to lead toxicity; however, the cellular effects of lead on neuronal development are not well understood. The effect of exposure to nanomolar concentrations of lead on several parameters of the developing retinotectal system of frog tadpoles was tested. Lead severely reduced the area and branchtip number of retinal ganglion cell axon arborizations within the optic tectum at submicromolar concentrations. These effects of lead on neuronal growth are more dramatic and occur at lower exposure levels than previously reported.

机译：发育中的大脑特别容易导致铅中毒。然而，铅对神经元发育的细胞作用尚不十分清楚。测试了暴露于纳摩尔浓度的铅对青蛙t发育中的视网膜-直肠系统的几个参数的影响。铅严重降低了在亚微摩尔浓度的视神经室内的视网膜神经节细胞轴突乔化的面积和分支尖端数量。铅对神经元生长的这些影响更为显着，并且比以前报道的暴露水平更低。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第18期|p.9915-9920|共6页
作者
Hollis T. Cline; Sonia Witte; Keith W. Jones;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Low lead levels stunt neuronal growth in a reversible manner. [O] . H T Cline, S Witte, K W Jones 1996

机译：低铅水平以可逆的方式阻碍神经元的生长。
7. Low lead levels stunt neuronal growth in a reversible manner. [O] . Cline, H T, Witte, S, Jones, K W 1996

机译：低铅水平以可逆的方式阻碍神经元的生长。

Low lead levels stunt neuronal growth in a reversible manner

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