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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >CD30/TNF receptor-associated factor interaction: NF-kB activation and binding specificity
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CD30/TNF receptor-associated factor interaction: NF-kB activation and binding specificity

机译:CD30 / TNF受体相关因子相互作用:NF-kB激活和结合特异性

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摘要

CD30 is a member of the tumor necrosis factor (TNF) receptor superfamily. CD30 is expressed on normal activated lymphocytes, on several virally transformed T- or B-cell lines and on neoplastic cells of Hodgkin's lym- phoma. The interaction of CD30 with its ligand induces pleiotropic effects on cells resulting in prolifer- ation, differentiation, or death.
机译:CD30是肿瘤坏死因子(TNF)受体超家族的成员。 CD30在正常的活化淋巴细胞,几种病毒转化的T或B细胞系以及霍奇金淋巴瘤的赘生性细胞上表达。 CD30及其配体之间的相互作用会引起细胞多效性,从而导致细胞增殖,分化或死亡。

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