Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules

Chris M. Farnet; Beibei Wang; J. Russell Lipford

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Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules

机译：小分子对HIV-1预整合复合物和纯化的整合酶蛋白的差异抑制

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To replicate, HIV-1 must integrate a cDNA copy of the viral RNA genome into a chromosome of the host. The integration system is a promising target for antiretroviral agents, but to date no clinically useful integration inhibitors have been identified. Previous screens for integrase inhibitors have assayed inhibition of reactions containing HIV-1 inte- grase purified from an Escherichia coli expression system.

机译：为了复制，HIV-1必须将病毒RNA基因组的cDNA拷贝整合到宿主的染色体中。整合系统是抗逆转录病毒药物的有希望的靶标，但是迄今为止尚未鉴定出临床上有用的整合抑制剂。先前对整合酶抑制剂的筛选已测定了对从大肠杆菌表达系统纯化的含有HIV-1整合酶的反应的抑制作用。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第18期|p.9742- 9747|共6页
作者
Chris M. Farnet; Beibei Wang; J. Russell Lipford;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication. [J] . Vandegraaff N, Devroe E, Turlure F, Virology . 2006,第2期

机译：整合酶相互作用蛋白在整合前复合物功能和HIV-1复制中的作用：上皮来源的生长因子（LEDGF）/ p75和肝癌来源的生长因子相关蛋白2（HRP2）的生化和遗传分析。
2. Complexes of HIV-1 integrase with HAT proteins: multiscale models, dynamics, and hypotheses on allosteric sites of inhibition. [J] . Di Fenza A, Rocchia W, Tozzini V Proteins: Structure, Function, and Genetics . 2009,第4期

机译：HIV-1的复合物与HAT蛋白整合：多尺度模型，动力学和关于变构抑制位点的假设。
3. Identification of host proteins associated with HIV-1 preintegration complexes isolated from infected CD4+ cells [J] . Nidhanapati K Raghavendra, Nikolozi Shkriabai, Robert LJ Graham, Retrovirology . 2010,第S1期

机译：从感染的CD4 + 细胞分离的HIV-1预整合复合体相关宿主蛋白的鉴定
4. Comparative study of Differential Evolutionary-Binary Particle Swarm Optimization (DE-BPSO) algorithm as a feature selection technique with different linear regression models for analysis of HIV-1 Integrase Inhibition features of Aryl β-Diketo Acids [C] . Falguni Thakor, Ahmad Reza Hadaegh, Xiaoyu Zhang International Conference on Bioinformatics and Computational Biology . 2017

机译：差分进化二元粒子群优化（DE-BPSO）算法作为具有不同线性回归模型的特征选择技术的对比研究分析芳基β-Diketo酸的HIV-1整合酶抑制特征
5. Novel modes of HIV-1 integrase inhibition [D] . Serrao, Erik 2013

机译：HIV-1整合酶抑制的新模式
6. Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules. [O] . C M Farnet, B Wang, J R Lipford, 1996

机译：小分子对HIV-1预整合复合物和纯化的整合酶蛋白的差异抑制。
7. Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules. [O] . Farnet, C M, Wang, B, Lipford, J R, 1996

机译：小分子对HIV-1预整合复合物和纯化的整合酶蛋白的差异抑制。

Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules

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