SNAP-25 and synaptotagmin involvement in the final Ca~2+-dependent triggering of neurotransmitter exocytosis

Prashant P. Mehta; Elena Battenberg; Michael C. Wilson

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SNAP-25 and synaptotagmin involvement in the final Ca~2+-dependent triggering of neurotransmitter exocytosis

机译：SNAP-25和突触结合蛋白参与神经递质胞吐作用的最终Ca〜2 +依赖性触发

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In neurons, depolarization induces Ca~2+ in- flux leading to fusion of synaptic vesicles docked at the active zone for neurotransmitter release. While a number of proteins have now been identified and postulated to participate in the assembly and subsequent disengagement of a vesicle docking complex for fusion, the mechanism that ultimately triggers neuroexocytosis remains elusive.

机译：在神经元中，去极化诱导Ca〜2 +流入，导致停靠在神经递质释放活性区的突触小泡融合。虽然现在已经鉴定出许多蛋白质，并假定它们参与了囊泡对接复合物的组装和随后的分离以进行融合，但最终触发神经胞吐的机制仍然难以捉摸。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第19期|p.10471-10476|共6页
作者
Prashant P. Mehta; Elena Battenberg; Michael C. Wilson;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Ca(2+)-Dependent Synaptotagmin Binding to SNAP-25 Is Essential for Ca(2+)-Triggered Exocytosis. [J] . Zhang X, Kim Miller MJ, Fukuda M, Neuron . 2002,第4期

机译：Ca（2+）依赖于Synaptotagmin绑定到SNAP-25是必不可少的Ca（2 +）-触发的胞吐作用。
2. Synaptotagmin-1 and Synaptotagmin-7 Trigger Synchronous and Asynchronous Phases of Neurotransmitter Release [J] . BacajT., WuD., YangX., Neuron . 2013,第4期

机译：Synaptotagmin-1和Synaptotagmin-7触发神经递质释放的同步和异步阶段
3. Synaptotagmin-1 and Synaptotagmin-7 Trigger Synchronous and Asynchronous Phases of Neurotransmitter Release [J] . BacajT., WuD., YangX., Neuron . 2013,第4期

机译：SynaptoTagmin-1和Synaptotagmin-7触发神经传递释放的同步和异步阶段
4. CONCURRENT QUANTIFICATION OF SYNAPTOTAGMIN-1 AND SNAP-25 IN CLINICALLY RELEVANT VOLUMES OF CSF BY IMMUNOAFFINITY LC-MS/MS [C] . Ann Brinkmalm, Annika Ohrfelt, Lutz Frolich, International Mass Spectrometry Conference . 2018

机译：通过免疫亲和LC-MS / MS在临床相关体积的CSF中同时定量Synaptagmin-1和Snap-25
5. The roles of SNAP-25 and synaptotagmin in the late stages of regulated exocytosis. [D] . Zhang, Xiaodong. 2002

机译：SNAP-25和突触结合素在调控胞吐的晚期阶段的作用。
6. SNAP-25 and synaptotagmin involvement in the final Ca(2+)-dependent triggering of neurotransmitter exocytosis. [O] . P P Mehta, E Battenberg, M C Wilson 1996

机译：SNAP-25和synaptotagmin参与最终的Ca（2+）依赖神经递质胞吐作用的触发。
7. SNAP-25 and synaptotagmin involvement in the final Ca(2+)-dependent triggering of neurotransmitter exocytosis. [O] . Mehta, P P, Battenberg, E, Wilson, M C 1996

机译：SNAP-25和synaptotagmin参与最终的Ca（2+）依赖神经递质胞吐作用的触发。

SNAP-25 and synaptotagmin involvement in the final Ca~2+-dependent triggering of neurotransmitter exocytosis

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