The natural killer cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its major histocompatibility complex class I ligand

Michael Orihuela; David H. Margulies; Wayne M. Yokoyama

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The natural killer cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its major histocompatibility complex class I ligand

机译：天然杀伤细胞受体Ly-49A在其主要组织相容性复合物I类配体上识别肽诱导的构象决定簇

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Natural killer (NK) cells are inhibited from killing cellular targets by major histocompatibility complex (MHC) class I molecules. In the mouse, this can be mediated by the Ly-49A NK cell receptor that specifically binds the H-2D~d MHC class I molecule, then inhibits NK cell activity. Previous experiments have indicated that Ly-49A recognizes the 1/2 domains of MHC class I and that no specific MHC-bound peptide appeared to be involved.

机译：自然杀手（NK）细胞被主要的组织相容性复合体（MHC）I类分子抑制杀伤细胞靶标。在小鼠中，这可以由Ly-49A NK细胞受体介导，该受体特异性结合H-2D〜d MHC I类分子，然后抑制NK细胞活性。先前的实验表明，Ly-49A识别I类MHC的1/2结构域，并且似乎没有涉及MHC结合的特定肽。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第21期|p.11792-11797|共6页
作者
Michael Orihuela; David H. Margulies; Wayne M. Yokoyama;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities. [J] . A Moretta, M Vitale, C Bottino, The Journal of Experomental Medicine . 1993,第2期

机译：P58分子是人类自然杀伤（NK）细胞中主要组织相容性复合体（MHC）I类分子的推定受体。抗p58抗体可重建显示不同特异性的NK克隆中MHC I类保护的细胞的裂解。
2. The Functional Binding Site for the C-Type Lectin–Like Natural Killer Cell Receptor Ly49a Spans Three Domains of Its Major Histocompatibility Complex Class I Ligand [J] . Naoki Matsumoto, Motoaki Mitsuki, Kyoko Tajima, The Journal of Experomental Medicine . 2001,第2期

机译：C型凝集素样自然杀伤细胞受体Ly49a的功能结合位点跨越了其主要组织相容性复合体I类配体的三个结构域
3. Interferon-γ Up-regulates major-histocompatibility-complex class I-related chain A expression and enhances major-histocompatibility-complex class I-related chain A-mediated cytolysis of human corneal epithelium by natural killer cells in vitro [J] . HongJ., ShaoT., SunX., Journal of interferon and cytokine research: The official journal of the International Society for Interferon and Cytokine Research . 2012,第3期

机译：干扰素-γ上调自然杀伤细胞对人角膜上皮的主要组织相容性复杂的I类相关链A的表达并增强主要组织相容性I类相关的链A介导的细胞溶解
4. Quantification of low-affinity kinetics between cancer immunity relevant ligands and natural killer cell receptors with a self-induced back-action actuated nanopore electrophoresis (SANE) sensor [C] . George Alexandrakis, Sai Santosh Sasank Peri, Manoj Kumar Sabnani, Conference on Optical Trapping and Optical Micromanipulation . 2020

机译：用自诱导的背动作驱动纳米孔电泳（SANE）传感器的癌症免疫相关配体和天然杀伤细胞受体之间的低亲和力动力学的定量
5. Defining the mechanism of MHC class II peptide editing by HLA-DM: I. HLA-DM recognizes the flexible conformation of major histocompatibility complex class II. II. Mapping the interaction surface of DR1 with DM by superantigen blocking. III. Determinati [D] . Chou, Chih-Ling. 2003

机译：定义HLA-DM编辑MHC II类肽的机制：I. HLA-DM识别II类主要组织相容性复合物的柔性构象。二。通过超抗原阻断作用绘制DR1与DM的相互作用表面。三，确定性
6. The natural killer cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its major histocompatibility complex class I ligand. [O] . M Orihuela, D H Margulies, W M Yokoyama 1996

机译：天然杀伤细胞受体Ly-49A在其主要组织相容性复合物I类配体上识别肽诱导的构象决定簇。
7. The natural killer cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its major histocompatibility complex class I ligand. [O] . Orihuela, M, Margulies, D H, Yokoyama, W M 1996

机译：天然杀伤细胞受体Ly-49A在其主要组织相容性复合物I类配体上识别肽诱导的构象决定簇。

The natural killer cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its major histocompatibility complex class I ligand

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