p21~Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex

Junjie Chen; Steven Chen; Partha Saha

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p21~Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex

机译：p21〜Cip1 / Waf1通过将细胞核抗原增殖到DNA复制复合物中来破坏人Fen1的募集

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Fen1 or maturation factor 1 is a 5'-3' exo- nuclease essential for the degradation of the RNA primer- DNA junctions at the 5' ends of immature Okazaki fragments prior to their ligation into a continuous DNA strand. The gene is also necessary for repair of damaged DNA in yeast. We report that human proliferating-cell nuclear antigen (PCNA) associates with human Fen1 with a K_d of 60 nM and an apparent stoichiometry of three Fen1 molecules per PCNA trimer.

机译：Fen1或成熟因子1是5'-3'核酸外切酶，对于连接未成熟的Okazaki片段的5'末端的RNA引物-DNA连接，然后连接成连续的DNA链来说，这是必不可少的。该基因对于修复酵母中受损的DNA也是必需的。我们报告，人类增殖细胞核抗原（PCNA）与人类Fen1的K_d为60 nM，每个PCNA三聚体的表观化学计量为三个Fen1分子。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第21期|p.11597-11602|共6页
作者
Junjie Chen; Steven Chen; Partha Saha;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Transcriptional activation of p21(WAF1/CIP1) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts [J] . Kim Hyun-Seok, Heo Jee-In, Park Seong-Hoon, Molecular biology reports . 2014,第4期

机译：p21（WAF1 / CIP1）的转录激活是通过人类胚胎成纤维细胞复制衰老过程中的DNA结合活性增强和p53与Sp1之间的相互作用通过磷酸化介导
2. Ciz1, a p21(Cip1/Waf1)-interacting zinc finger protein and DNA replication factor, is a novel molecular partner for human enhancer of rudimentary homolog [J] . Lukasik A, Uniewicz KA, Kulis M, The FEBS journal . 2008,第2期

机译：Ciz1，一种与p21（Cip1 / Waf1）相互作用的锌指蛋白和DNA复制因子，是人类基本同源增强子的新型分子伴侣
3. Functional dissection of proliferating-cell nuclear antigens (1 and 2) in human malarial parasite Plasmodium falciparum: possible involvement in DNA replication and DNA damage response [J] . Abhijit?S. Deshmukh, Khadija Banu, Naidu Subbarao, The biochemical journal . 2015,第1期

机译：人疟原虫恶性疟原虫中增殖细胞核抗原（1和2）的功能解剖：可能参与DNA复制和DNA损伤反应
4. Influence of Ras and Rho on p21~(Waf1/cip1) Protein Stability [C] . M. Coleman, C.J. Marshall and M.F. Olson NATO Advanced Study Institute on Molecular Mechanisms of Signal Transduction . 2000

机译：Ras和Rho对P21〜（WAF1 / CIP1）蛋白质稳定性的影响
5. The role and regulation of p21(WAF1/CIP1) in myelopoiesis. [D] . Ghanem, Louis R. 2005

机译：p21（WAF1 / CIP1）在骨髓生成中的作用和调控。
6. p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex. [O] . U Chen, S Chen, P Saha, 1996

机译：p21Cip1 / Waf1通过将细胞核抗原增殖到DNA复制复合物中来破坏人Fen1的募集。
7. p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex. [O] . Chen, U, Chen, S, Saha, P, 1996

机译：p21Cip1 / Waf1通过将细胞核抗原增殖到DNA复制复合物中来破坏人Fen1的募集。

p21~Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex

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