On the failure of de novo-designed peptides as biocatalysts

M. J. Corey; E. Corey

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On the failure of de novo-designed peptides as biocatalysts

机译：从头设计的肽作为生物催化剂的失败

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While the elegance and efficiency of enzy- matic catalysis have long tempted chemists and biochemists with reductionist leanings to try to mimic the functions of natural enzymes in much smaller peptides, such efforts have only rarely produced catalysts with biologically interesting properties. However, the advent of genetic engineering and hybridoma technology and the discovery of catalytic RNA have led to new and very promising alternative means of biocatalyst development.

机译：长期以来，酶催化的高雅性和效率一直吸引着化学家和生物化学家，他们倾向于还原剂，他们试图模仿小得多的肽中天然酶的功能，但这种努力很少能生产出具有生物学特性的催化剂。但是，基因工程和杂交瘤技术的出现以及催化RNA的发现导致了新的，非常有希望的生物催化剂开发替代手段。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第21期|p.11428-11434|共7页
作者
M. J. Corey; E. Corey;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Peptide-based immunoadsorbents: Molecular grafting of IgG-Fc-binding epitopes of Protein A onto a de novo-designed helix-loop-helix peptide [J] . KawabataK., NagaiH., KonishiN., Bioorganic and medicinal chemistry . 2014,第6期

机译：基于肽的免疫吸附剂：将蛋白A的IgG-Fc结合表位分子嫁接到从头设计的螺旋-环-螺旋肽上
2. Peptide-based immunoadsorbents: Molecular grafting of IgG-Fc-binding epitopes of Protein A onto a de novo-designed helix-loop-helix peptide [J] . KawabataK., NagaiH., KonishiN., Bioorganic and medicinal chemistry . 2014,第6期

机译：基于肽的免疫吸入性：蛋白A的IgG-Fc结合表位的分子接枝到De Novo-Deparing的螺旋环螺旋肽上
3. CONTROLLING TOPOLOGY AND NATIVE-LIKE BEHAVIOR OF DE NOVO-DESIGNED PEPTIDES - DESIGN AND CHARACTERIZATION OF ANTIPARALLEL FOUR-STRANDED COILED COILS [J] . Betz SF, Degrado WF Biochemistry . 1996,第21期

机译：从头设计肽的拓扑学控制和原始行为-反平行四层螺旋卷的设计和表征
4. Purity of mushroom tyrosinase as a biocatalyst for biomaterial synthesis affects the stability of therapeutic peptides [C] . M. Racheva, O. Romero, K.-K. Julich-Gruner Materials Research Society symposium . 2015

机译：蘑菇酪氨酸酶作为生物材料合成生物催化剂的纯度会影响治疗性肽的稳定性
5. Use of metal-binding de novo-designed alpha-helical peptides in the study of metalloprotein structures [D] . Dieckmann, Gregg Richard 1995

机译：金属结合从头设计的α-螺旋肽在金属蛋白结构研究中的用途
6. On the failure of de novo-designed peptides as biocatalysts. [O] . M J Corey, E Corey 1996

机译：从头设计的肽作为生物催化剂的失败。
7. On the failure of de novo-designed peptides as biocatalysts. [O] . Corey, M J, Corey, E 1996

机译：从头设计的肽作为生物催化剂的失败。

On the failure of de novo-designed peptides as biocatalysts

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