Transposition of DNase hypersensitive chromatin to the nuclear periphery coincides temporally with nerve growth factor-induced up-regulation of gene expression in PC12 cells

Paul C. Park; U. De Boni

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Transposition of DNase hypersensitive chromatin to the nuclear periphery coincides temporally with nerve growth factor-induced up-regulation of gene expression in PC12 cells

机译：DNase敏感染色质转位至核周围在时间上与神经生长因子诱导PC12细胞基因表达的上调相吻合

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To test the hypothesis that the nonrandom organization of the contents of interphase nuclei represents a compartmentalization of function, we examined the relative, spatial relationship of small nuclear ribonucleoproteins (snRNPs) and of DNase I hypersensitive chromatin (DHC) in rat pheochromocytoma cells. In controls, DHC and snRNPs colocalized as pan-nuclear speckles. During nerve growth factor-induced differentiation, both snRNPs and DHC mi- grated to the nuclear periphery with the migration of DHC preceding that of snRNPs, resulting in their transient sepa- ration.

机译：为了检验这一假设，即相间核内容的非随机组织代表功能的分隔，我们检查了大鼠嗜铬细胞瘤细胞中小核糖核糖核蛋白（snRNPs）和DNase I超敏染色质（DHC）的相对，空间关系。在对照中，DHC和snRNPs共定位为泛核斑点。在神经生长因子诱导的分化过程中，随着DHC的迁移先于snRNPs迁移，snRNPs和DHC均迁移至核周围，从而导致其瞬时分离。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第21期|p.11646-11651|共6页
作者
Paul C. Park; U. De Boni;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Nerve growth factor-induced up-regulation of cytosolic phospholipase A2alpha level in rat PC12 cells. [J] . Akiyama N, Hatori Y, Takashiro Y, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2004,第3期

机译：神经生长因子诱导大鼠PC12细胞中胞质磷脂酶A2alpha水平的上调。
2. Nerve growth factor-induced expression of the GTP cyclohydrolase I gene via Ras/MEK pathway in PC12D cells. [J] . Ito T, Suzuki T, Ichinose H Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2005,第2期

机译：神经生长因子通过Ras / MEK途径在PC12D细胞中诱导GTP环水解酶I基因的表达。
3. Overexpression of Ca2+/calmodulin-dependent protein kinase II in PC12 cells alters cell growth, morphology, and nerve growth factor-induced differentiation. [J] . Masse T, Kelly PT The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 1997,第3期

机译：Ca12 + /钙调蛋白依赖性蛋白激酶II在PC12细胞中的过表达改变细胞生长，形态和神经生长因子诱导的分化。
4. Effects of low-intensity pulsed ultrasound on nerve growth factor-induced neurite outgrowth mainly through ERK-CREB pathway in PC12 cells [C] . Lu Zhao, Yi Feng, Hong Hu, IEEE International Ultrasonics Symposium . 2015

机译：低强度脉冲超声主要通过PC12细胞中的ERK-CREB途径对神经生长因子诱导的神经突生长的影响
5. The regulation of annexin II gene expression and function during nerve growth factor-induced differentiation of PC-12 cells. [D] . Jacovina, Andrew Thomas. 2000

机译：神经生长因子诱导PC-12细胞分化过程中Annexin II基因表达和功能的调节。
6. Transposition of DNase hypersensitive chromatin to the nuclear periphery coincides temporally with nerve growth factor-induced up-regulation of gene expression in PC12 cells. [O] . P C Park, U De Boni 1996

机译：DNase敏感染色质转位至核周边在时间上与神经生长因子诱导PC12细胞中基因表达的上调一致。
7. Transposition of DNase hypersensitive chromatin to the nuclear periphery coincides temporally with nerve growth factor-induced up-regulation of gene expression in PC12 cells. [O] . Park, P C, De Boni, U 1996

机译：DNase敏感染色质转位至核周边在时间上与神经生长因子诱导PC12细胞中基因表达的上调一致。

Transposition of DNase hypersensitive chromatin to the nuclear periphery coincides temporally with nerve growth factor-induced up-regulation of gene expression in PC12 cells

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