Mechanism of activation for Zap-70 catalytic activity

Philip V. LoGrasso; Julio Hawkins; Lori J. Frank

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Mechanism of activation for Zap-70 catalytic activity

机译：Zap-70催化活性的激活机制

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There is a growing body of evidence, include- ing data from human genetic and T-cell receptor function studies, which implicate a -associated protein of Mr 70,000 (Zap-70) as a critical protein tyrosine kinase in T-cell acti- vation and development. During T-cell activation, Zap-70 becomes associated via its src homology type 2 (SH2) domains with tyrosine-phosphorylated immune-receptor tyrosine ac- tivating motif (ITAM) sequences in the cytoplasmic chain of the T-cell receptor.

机译：越来越多的证据，包括来自人类遗传学和T细胞受体功能研究的数据，这暗示了70,000先生（Zap-70）的相关蛋白是T细胞活化中的关键蛋白酪氨酸激酶。和发展。在T细胞活化过程中，Zap-70通过其src同源2型（SH2）结构域与T细胞受体胞质链中的酪氨酸磷酸化免疫受体酪氨酸激活基序（ITAM）序列相关。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第22期|p.12165-12170|共6页
作者
Philip V. LoGrasso; Julio Hawkins; Lori J. Frank;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity. [J] . N Isakov, R L Wange, W H Burgess, The Journal of Experomental Medicine . 1995,第1期

机译：ZAP-70对T细胞受体基于酪氨酸的激活基序的结合特异性：ZAP-70的串联SH2结构域以不同的亲和力结合不同的基于酪氨酸的激活基序。
2. Mechanism of activation of cAMP-dependent protein kinase: In Mucor rouxii the apparent specific activity of the cAMP-activated holoenzyme is different than that of its free catalytic subunit [J] . Zaremberg V., Moreno S., Donella-Deana A. Archives of Biochemistry and Biophysics . 2000,第1期

机译：cAMP依赖性蛋白激酶激活的机制：在Mucor rouxii中，cAMP激活的全酶的表观比活性与其游离催化亚基的表观比活性不同
3. Age-related impairment of p56lck and ZAP-70 activities in human T lymphocytes activated through the TcR/CD3 complex. [J] . Fulop T Jr, Gagne D, Goulet AC, Experimental Gerontology . 1999,第2期

机译：通过TcR / CD3复合物激活的人类T淋巴细胞中与年龄相关的p56lck和ZAP-70活性受损。
4. CATALYTIC DEHYDROCHLORINATION OF 2-CHLOROPROPANE OVER ACTIVATED CARBONS. THE EFFECT OF CHEMICAL NATURE OF SURFACE ON CATALYTIC ACTIVITY OF CARBON [C] . G. S. Szymanski, S. Zietek Carbon '01 . 2001

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机译：具有多个桥联配体的选定三钌簇中电子转移和氢活化的机理。第一部分。三氢三钌（亚烷基）簇中自由基反应性的减弱。通过歧化路径分解47电子簇自由基的电化学和动力学。第二部分通过（mu-hydrogen）（2）钌（3）（一氧化碳）（8）（mu-phosphorus（）的金属-金属键上氢的可逆氧化加成反应的动力学和机理激活过渡金属中心的分子氢t-BU）（2））（2）。
6. Mechanism of activation for Zap-70 catalytic activity. [O] . P V LoGrasso, J Hawkins, L J Frank, 1996

机译：Zap-70催化活性的激活机制。
7. Mechanism of activation for Zap-70 catalytic activity. [O] . LoGrasso, P V, Hawkins, J, Frank, L J, 1996

机译：Zap-70催化活性的激活机制。

Mechanism of activation for Zap-70 catalytic activity

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