DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state

Maryline Mancini; Michelle Hadchouel; Heather L. Davis

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DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state

机译：乙型肝炎表面抗原慢性携带者状态的转基因小鼠模型中的DNA介导的免疫

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Transgenic mice expressing the sequences coding for the envelope proteins of the hepatitis B virus (HBV) in the liver have been used as a model of the HBV chronic carrier state. We evaluated the possibility of inducing a specific immune response to the viral envelope antigens and thus potentially controlling chronic HBV infection. Using HBV-specific DNA-mediated immunization in this transgenic model, we show that the immune response induced after a single intramuscular injection of DNA resulted in the com- plete clearance of circulating hepatitis B surface antigen and in the long-term control of transgene expression in hepato- cytes.

机译：表达肝中乙型肝炎病毒（HBV）包膜蛋白编码序列的转基因小鼠已被用作HBV慢性携带者状态的模型。我们评估了诱导针对病毒包膜抗原的特异性免疫反应并因此潜在控制慢性HBV感染的可能性。在该转基因模型中使用HBV特异性DNA介导的免疫接种，我们表明，单次肌内注射DNA诱导的免疫反应导致循环中乙型肝炎表面抗原的完全清除以及对转基因表达的长期控制。在肝细胞中。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第22期|p.12496-12501|共6页
作者
Maryline Mancini; Michelle Hadchouel; Heather L. Davis;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Regulation of hepatitis B virus mRNA expression in a hepatitis B surface antigen transgenic mouse model by IFN-gamma-secreting T cells after DNA-based immunization. [J] . Mancini M, Hadchouel M, Tiollais P, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1998,第10期

机译：基于DNA的免疫后，IFN-γ分泌的T细胞在乙型肝炎表面抗原转基因小鼠模型中调节乙型肝炎病毒mRNA表达。
2. Regulation of Hepatitis B Virus mRNA Expression in a Hepatitis B Surface Antigen Transgenic Mouse Model by IFN-γ-Secreting T Cells After DNA-Based Immunization [J] . Maryline Mancini, Michelle Hadchouel, Pierre Tiollais, The journal of immunology . 1998,第10期

机译：DNA免疫后通过IFN-γ分泌T细胞调节乙型肝炎表面抗原转基因小鼠模型中乙型肝炎病毒mRNA的表达
3. Induction of antibodies to the PreS region of surface antigens of woodchuck hepatitis virus (WHV) in chronic carrier woodchucks by immunizations with WHV surface antigens. [J] . Lu M, Klaes R, Menne S, Journal of Hepatology: The Journal of the European Association for the Study of the Liver . 2003,第3期

机译：通过用WHV表面抗原免疫接种诱导慢性携带者土拨鼠中土拨鼠肝炎病毒（WHV）表面抗原PreS区的抗体。
4. Autoimmune hepatitis in transgenic mouse models: what lessons can be learnt? [C] . P. BERTOLINO, D. G. BOWEN, M. ZEN, Falk Symposium . 2005

机译：转基因小鼠模型中的自身免疫性肝炎：可以学习哪些课程？
5. Incidence, Durability, and Clinical Outcomes of Hepatitis B Surface Antigen Seroclearance in Patients with Chronic Hepatitis B [D] . Yip, Cheuk Fung. 2019

机译：慢性乙型肝炎患者乙型肝炎表面抗原血管疮的发病率，耐久性和临床结果
6. DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state. [O] . M Mancini, M Hadchouel, H L Davis, 1996

机译：在乙型肝炎表面抗原慢性携带者状态的转基因小鼠模型中进行DNA介导的免疫。
7. DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state. [O] . Mancini, M, Hadchouel, M, Davis, H L, 1996

机译：在乙型肝炎表面抗原慢性携带者状态的转基因小鼠模型中进行DNA介导的免疫。

DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state

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