The cell surface metalloprotease/disintegrin Kuzbanian is required for axonal extension in Drosophila

Douglas Fambrough; Duojia Pan; Gerald M. Rubin

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The cell surface metalloprotease/disintegrin Kuzbanian is required for axonal extension in Drosophila

机译：果蝇轴突延伸需要细胞表面金属蛋白酶/解整合蛋白库兹班人

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It has long been suspected that proteolytic activity associated with advancing growth cones may be required for axon extension. We have isolated mutations in the kuzbanian (kuz) gene, which is expressed in the nervous system and encodes a putative zinc metalloprotease with a disintegrin domain. Drosophila embryos with loss-of-function mutations in kuz have dramatic defects in the development of central nervous system axon pathways, with many axons stalling and failing to extend through the nerve cord. This phenotype is rescued by panneural expression of kuz mRNA in the embryo. These results show that the Kuz metalloprotease is required for axon extension, suggesting a requirement for proteolytic activity at the growth cone surface.

机译：长期以来一直怀疑轴突延伸可能需要与生长锥相关的蛋白水解活性。我们已经在kuzbanian（kuz）基因中分离出突变，该基因在神经系统中表达，并编码带有整合素结构域的推定锌金属蛋白酶。果蝇在库兹族中具有功能丧失突变的果蝇胚胎在中枢神经系统轴突通路的发育中存在严重缺陷，许多轴突停滞并且无法延伸穿过神经线。该表型通过胚胎中kuz mRNA的神经上表达而得以挽救。这些结果表明，Kuz金属蛋白酶是轴突延伸所必需的，表明在生长锥表面需要蛋白水解活性。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第23期|p.13233-13238|共6页
作者
Douglas Fambrough; Duojia Pan; Gerald M. Rubin;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17). [J] . Rizwan Romee, Bree Foley, Todd Lenvik, Blood: The Journal of the American Society of Hematology . 2013,第18期

机译：NK细胞CD16的表面表达和功能受整合素和金属蛋白酶17（ADAM17）的调节。
2. NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17). [J] . Rizwan Romee, Bree Foley, Todd Lenvik, Blood: The Journal of the American Society of Hematology . 2013,第18期

机译：NK细胞CD16表面表达和功能由Disinteglin和Metallopotease-17（Adam17）调节。
3. Optomotor-blind expression in glial cells is required for correct axonal projection across the Drosophila inner optic chiasm. [J] . Hofmeyer K, Kretzschmar D, Pflugfelder GO Developmental biology . 2008,第1期

机译：为了在果蝇内部视神经交叉症中正确的轴突投射，需要神经胶质细胞中的光动力盲表达。
4. Ile-Lys-Val-Ala-Val and Leu-Arg-Glu peptide signaling in combination with matrix metalloprotease cleavable erosslinkers alter extracellular matrix degrading enzyme expression and axon extension in encapsulated human induced pluripotent stem cell derived neural stem cells. [C] . T. Hiran Perera, Laura A. Smith Callahan Society for Biomaterials annual meeting and exposition . 2019

机译：Ile-Lys-Val-Ala-Val和Leu-Arg-Glu肽信号转导与基质金属蛋白酶可切割的erosslinker结合改变封装的人诱导多能干细胞衍生的神经干细胞中细胞外基质降解酶的表达和轴突延伸。
5. Characterization of roles for the disintegrin and metalloproteases, kuzbanian and tumor necrosis factor-alpha converting enzyme, in mammalian Notch signaling. [D] . Cagavi Bozkulak, Esra. 2009

机译：表征哺乳动物中的Notch信号中整合素和金属蛋白酶，库兹班和肿瘤坏死因子-α转化酶的作用。
6. Inaugural Article: The cell surface metalloprotease/disintegrin Kuzbanian is required for axonal extension in Drosophila [O] . Douglas Fambrough, Duojia Pan, Gerald M. Rubin, 1996

机译：就职文章：细胞表面金属蛋白酶/解整合蛋白库兹班人在果蝇中需要轴突扩展
7. The cell surface metalloprotease/disintegrin Kuzbanian is required for axonal extension in Drosophila [O] . D. Fambrough, D. Pan, G. M. Rubin, 1996

机译：果蝇中的轴突延伸需要细胞表面金属蛋白酶/ Disintegrin Kuzbanian
8. Metalloprotease/Disintegrin Proteins and Mammary Carcinoma Progression [R] . Pytela, R. 2000

机译：金属蛋白酶/解整合素蛋白和乳腺癌进展

The cell surface metalloprotease/disintegrin Kuzbanian is required for axonal extension in Drosophila

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