Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous systemby disrupted galactocerebroside synthesis

Andreas Bosio; Erika Binczek; Wilhelm Stoffel

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Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous systemby disrupted galactocerebroside synthesis

机译：中枢神经系统和外周神经系统中髓鞘膜脂双层的功能破坏，破坏了半乳糖脑苷脂的合成

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The lipid bilayer of the myelin membrane of the central nervous system (CNS) and the peripheral nervous system (PNS) contains the oligodendrocyte- and Schwann cell-specific glycosphingolipids galactocerebrosides (GalC) and GalC-derived sulfatides (sGalC). We have generated a UDP-galactose ceramide galactosyltransferase (CGT) null mutant mouse (cgt~-/-) with CNS and PNS myelin completely depleted of GalC and derived sGalC. Oligodendrocytes and Schwann cells are unable to restore the structure and function of these galactosphingolipids to maintain the insulator func- tion of the membrane bilayer.

机译：中枢神经系统（CNS）和外周神经系统（PNS）的髓磷脂膜的脂质双层包含少突胶质细胞和雪旺氏细胞特异性糖鞘脂半乳糖苷（GalC）和GalC衍生的硫化物（sGalC）。我们已经生成了UDP-半乳糖神经酰胺半乳糖基转移酶（CGT）无效突变小鼠（cgt-//），其中CNS和PNS髓磷脂完全耗尽了GalC和衍生的sGalC。少突胶质细胞和雪旺氏细胞无法恢复这些半乳糖鞘脂的结构和功能，从而无法维持膜双层的绝缘子功能。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第23期|p.13280-13285|共6页
作者
Andreas Bosio; Erika Binczek; Wilhelm Stoffel;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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机译：髓磷脂蛋白脂蛋白，碱性蛋白，髓磷脂相关糖蛋白的小亚型和p42MAPK与中枢神经系统髓磷脂的Triton X-100提取物有关。
2. Functional central nervous system myelin repair in an adult mouse model of demyelination caused by proteolipid protein overexpression. [J] . Espinosa Jeffrey A, Hitoshi S, Zhao P, Journal of Neuroscience Research . 2010,第8期

机译：蛋白脂质蛋白过度表达引起的成年小鼠脱髓鞘模型中的功能性中枢神经系统髓磷脂修复。
3. Murine macrophages stimulated with central and peripheral nervous system myelin or purified myelin proteins release inflammatory products. [J] . Constantinescu CS, Goodman DB, Hilliard B, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2000,第3期

机译：由中枢和外周神经系统髓磷脂或纯化的髓磷脂蛋白刺激的鼠巨噬细胞释放出炎性产物。
4. New method for the synthesis of membrane protein models using lipid bilayer assisted membrane peptide ligation [C] . Satoshi Ueda, Akira Otaka, Kenji Tomita International Peptide Symposium;European Peptide Symposium . 2005

机译：利用脂质双层辅助膜肽连接合成膜蛋白模型的新方法
5. I. OPTICAL PROPERTIES OF RAT BRAIN MYELIN. II. BINDING PROPERTIES AND PARTIAL CHARACTERIZATION OF PROTEOLIPIDS ISOLATED FROM THE CENTRAL NERVOUS SYSTEM [D] . PERKINS, JAMES GREGORY -1

机译：I.大鼠脑髓磷脂的光学性质。二。从中央神经系统分离出的蛋白脂的结合特性和部分表征
6. Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis [O] . Andreas Bosio, Erika Binczek, Wilhelm Stoffel 1996

机译：半乳糖脑苷脂合成中断中枢和周围神经系统中髓鞘膜脂质双层的功能破坏
7. Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis [O] . A. Bosio, E. Binczek, W. Stoffel 1996

机译：中央和外周神经系统中骨蛋白膜的脂质双层脂质双层的功能分解通过中断的半乳糖晶体合成

Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous systemby disrupted galactocerebroside synthesis

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