Interaction of measles virus glycoproteins with the surface of uninfected peripheral blood lymphocytes induces immunosuppression in vitro

Jorg Schlender; Jens-Jorg Schnorr; Pius Spielhofer

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Interaction of measles virus glycoproteins with the surface of uninfected peripheral blood lymphocytes induces immunosuppression in vitro

机译：麻疹病毒糖蛋白与未感染外周血淋巴细胞表面的相互作用诱导体外免疫抑制

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A marked suppression of immune function has long been recognized as a major cause of the high morbidity and mortality rate associated with acute measles. As a hallmark of measles virus (MV)-induced immunosup- pression, peripheral blood lymphocytes (PBLs) isolated from patients exhibit a significantly reduced capacity to proliferate in response to mitogens, allogens, or recall antigens. In an in vitro system we show that proliferation of naive PBLs [re- sponder cells (RCs)] in response to a variety of stimuli was significantly impaired after cocultivation with MV-infected, UV-irradiated autologous PBLs [presenter cells (PCs)].

机译：长期以来，人们公认免疫功能的显着抑制是与急性麻疹相关的高发病率和高死亡率的主要原因。作为麻疹病毒（MV）诱导的免疫抑制的标志，从患者身上分离出的外周血淋巴细胞（PBL）表现出对有丝分裂原，同种异体或召回抗原的增殖能力显着降低。在体外系统中，我们发现，与MV感染，紫外线照射的自体PBLs [呈递细胞（PC）]共同培养后，响应各种刺激的天然PBLs [响应细胞（RCs）]的增殖受到显着损害。。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第23期|p.13194-13199|共6页
作者
Jorg Schlender; Jens-Jorg Schnorr; Pius Spielhofer;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Use of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro [J] . Anthony Simmons, Robert P Whitehead, Andrey A Kolokoltsov, Virology Journal . 2006,第1期

机译：使用重组慢病毒假型与囊泡口炎病毒糖蛋白G通过在体外转导通过转导人体外周血淋巴细胞而有效地产生人抗癌嵌合T细胞
2. Measles virus induces apoptosis in uninfected bystander T cells and leads to granzyme B and caspase activation in peripheral blood mononuclear cell cultures. [J] . Vuorinen T, Peri P, Vainionpaa R European journal of clinical investigation . 2003,第5期

机译：麻疹病毒在未感染的旁观者T细胞中诱导凋亡，并在外周血单核细胞培养物中导致粒酶B和胱天蛋白酶激活。
3. Apoptosis induced in synchronized human immunodeficiency virus type 1-infected primary peripheral blood mononuclear cells is detected after the peak of CD4+T-lymphocyte loss and is dependent on the tropism of the gp120 envelope glycoprotein [J] . Lawson VA, Silburn KA, Gorry PR, Virology . 2004,第1期

机译：在CD4 + T淋巴细胞损失达到峰值后，检测到同步化的人类免疫缺陷病毒1型感染的原代外周血单核细胞中诱导的凋亡，这取决于gp120包膜糖蛋白的向性
4. Induction of Micronuclei by ~(153)Sm-EDTMP in Peripheral Blood Lymphocytes in vitro [C] . Kiriam F. Suzuki, Marcia A. da Silva, Maria Ines C. C. Guimaraes, International Conference on Nuclear Data for Science and Technology . 2002

机译：体外外周血淋巴细胞中〜（153）SM-EDTMP诱导微核
5. SURFACE IMMUNOGLOBULIN OF PERIPHERAL BLOOD LYMPHOCYTES AND BASOPHILS OF A AND B LOCUS HETEROZYGOUS RABBITS [D] . CABANA, VENERACION GARGANTA 1980

机译：外周血淋巴细胞和外周血淋巴细胞的免疫球蛋白
6. Interaction of measles virus glycoproteins with the surface of uninfected peripheral blood lymphocytes induces immunosuppression in vitro [O] . Jörg Schlender, Jens-Jörg Schnorr, Pius Spielhofer, 1996

机译：麻疹病毒糖蛋白与表面的相互作用未感染的外周血淋巴细胞诱导免疫抑制体外
7. Use of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro [O] . Kolokoltsov Andrey A, Whitehead Robert P, Simmons Anthony, 2006

机译：利用水疱性口炎病毒糖蛋白G假型的重组慢病毒通过体外转导人外周血淋巴细胞有效产生人抗癌嵌合T细胞

Interaction of measles virus glycoproteins with the surface of uninfected peripheral blood lymphocytes induces immunosuppression in vitro

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