A common mechanism for the biosynthesis of methoxy and cyclopropyl mycolic acids in Mycobacterium tuberculosis

Ying Yuan; Clifton E. Barry III

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A common mechanism for the biosynthesis of methoxy and cyclopropyl mycolic acids in Mycobacterium tuberculosis

机译：结核分枝杆菌中甲氧基和环丙基霉菌酸生物合成的常见机制

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Mycobacterium tuberculosis produces three classes of mycolic acids that differ primarily in the presence and nature of oxygen-containing substituents in the distal portion of the meromycolate branch. The methoxymycolate series has a methoxy group adjacent to a methyl branch, in addition to a cyclopropane in the proximal position. Using the gene for the enzyme that introduces the distal cyclopropane (cma1) as a probe, we have cloned and sequenced a cluster of genes coding for four highly homologous methyl transferases (mma1-4).

机译：结核分枝杆菌产生三类分支霉菌酸，其主要区别在于在菌丝体分支的远端部分中含氧取代基的存在和性质。除在近端位置的环丙烷外，甲氧基霉菌酸酯系列还具有与甲基分支相邻的甲氧基。使用引入远端环丙烷（cma1）的酶基因作为探针，我们克隆并测序了编码四种高度同源甲基转移酶（mma1-4）的基因簇。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第23期|p.12828-12833|共6页
作者
Ying Yuan; Clifton E. Barry III;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：脱氧杉和硫代乙二醇杆菌抑制结核分枝杆菌霉菌酸生物合成途径的常见机制
2. The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development [J] . Apoorva Bhatt, Virginie Molle, Gurdyal S. Besra, Molecular Microbiology . 2007,第6期

机译：结核分枝杆菌FAS-II缩合酶：它们在霉菌酸生物合成，耐酸性，发病机理和未来药物开发中的作用
3. The biosynthesis of mycolic acids in Mycobacterium tuberculosis relies on multiple specialized elongation complexes interconnected by specific protein-protein interactions [J] . Veyron-Churlet R, Bigot S, Guerrini O, Journal of Molecular Biology . 2005,第4期

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4. Shortening of Amino Acids from C-terminal of PZase as Basis of Pyrazinamide Resistance in P14 Isolate of Mycobacterium tuberculosis Strain [C] . Purkan, Redianti Galuh Novarizka, Rizka Aziz Ayuningsih, International Seminar on Molecular and Cellular Life Sciences . 2016

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5. The role of Mycothiol Biosynthesis in Pathogenesis and Drug Susceptibility of Mycobacterium tuberculosis. [D] . Xu, Xia. 2014

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6. A common mechanism for the biosynthesis of methoxy and cyclopropyl mycolic acids in Mycobacterium tuberculosis [O] . Ying Yuan, Clifton E. Barry III 1996

机译：生物合成甲氧基和甲氧基的常见机理结核分枝杆菌中的环丙基霉菌酸
7. Mycobacterium bovis BCG genes involved in the biosynthesis of cyclopropyl keto‐ and hydroxy‐mycolic acids [O] . Eugenie Dubnau, Marie‐Antoinette Lanéelle, Sonia Soares, 1997

机译：参与酮酮和羟基 - 氰酸的生物合成的分枝杆菌BOVI基因

A common mechanism for the biosynthesis of methoxy and cyclopropyl mycolic acids in Mycobacterium tuberculosis

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