Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can functionas an enhancer element in Drosophila

Theodor E. Haerry; Walter J. Gehring

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Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can functionas an enhancer element in Drosophila

机译：小鼠Hoxa-7基因的内含子含有保守的同源域结合位点，可在果蝇中充当增强子元件

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The 5' flanking sequences and the intron of the mouse Hoxa-7 gene were searched for regulatory elements that can function in Drosophila. Only the intron is able to activate a lacZ fusion gene in various tissues of Drosophila embryos. This enhancer function requires a cluster of three homeodomain binding sites (HB1-element) that are also found in the introns of other Hox genes as well as in a putative autoregulatory element of Ultrabithorax (Ubx), the Drosophila homolog of Hoxa-7.

机译：搜索5'侧翼序列和小鼠Hoxa-7基因的内含子以寻找可在果蝇中起作用的调控元件。只有内含子能够激活果蝇胚胎的各种组织中的lacZ融合基因。此增强子功能需要三个同源域结合位点（HB1-element）的簇，这些位点也在其他Hox基因的内含子以及Ultrabithorax（Ubx）的推定自动调节元件中也发现，Ubx是Hoxa-7的果蝇同源物。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第24期|p.13884-13889|共6页
作者
Theodor E. Haerry; Walter J. Gehring;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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机译：在果蝇胚胎小鼠中HOXA-4内含子功能中同源同源位点的保守簇作为增强剂
2. A conserved cluster of homeodomain binding sites in the mouse Hoxa-4 intron functions in Drosophila embryos as an enhancer that is directly regulated by Ultrabithorax [J] . Theodor E. Haerry, Walter J. Gehring Developmental biology . 1997,第1期

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6. Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can functionas an enhancer element in Drosophila [O] . Theodor E. Haerry, Walter J. Gehring 1996

机译：小鼠Hoxa-7基因的内含子包含保守的可以作为增强子功能的同源域结合位点果蝇
7. A conserved cluster of homeodomain binding sites in the mouse Hoxa-4 intron functions in Drosophila embryos as an enhancer that is directly regulated by Ultrabithorax [O] . Haerry Theodor E., Gehring Walter J. 1997

机译：小鼠Hoxa-4内含子中保守域的同源异型域结合位点簇在果蝇胚胎中起着直接由Ultrabithorax调控的增强子的作用

Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can functionas an enhancer element in Drosophila

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