Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity

Ronglan Zheng; Timothy M. Jenkins; Robert Craigie

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Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity

机译：锌折叠HIV-1整合酶的N末端结构域，促进多聚化并增强催化活性

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The N-terminal domain of HIV-1 integrase contains a pair of His and Cys residues (the HHCC motif) that are conserved among retroviral integrases. Although His and Cys residues are often involved in binding zinc, the HHCC motif does not correspond to any recognized class of zinc binding domain. We have investigated the binding of zinc to HIV-1 integrase protein and find that it binds zinc with a stoichiometry of one zinc per integrase monomer. Analysis of zinc binding to deletion derivatives of integrase locates the binding site to the N-terminal domain.

机译：HIV-1整合酶的N端结构域包含一对在逆转录病毒整合中保守的His和Cys残基（HHCC基序）。尽管His和Cys残基经常参与结合锌，但HHCC基序并不对应于任何公认的锌结合结构域类别。我们研究了锌与HIV-1整合酶蛋白的结合，发现它与锌的化学计量比为每整合酶单体结合一个锌。锌与整合酶缺失衍生物的结合分析将结合位点定位于N-末端结构域。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第24期|p.13659-13664|共6页
作者
Ronglan Zheng; Timothy M. Jenkins; Robert Craigie;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain [J] . Carayon Kevin, Leh Herve, Henry Etienne, Nucleic Acids Research . 2010,第11期

机译：HIV-1整合酶的合作和特异性DNA结合模式取决于金属辅因子的性质，并涉及含锌的N末端结构域
2. A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain [J] . Carayon Kevin, Leh Herve, Henry Etienne, Nucleic Acids Research . 2010,第11期

机译：HIV-1整合酶的合作和特异性DNA结合模式取决于金属辅因子的性质，并涉及含锌的N末端结构域
3. A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain [J] . Eric Deprez, Etienne Henry, Fran?oise Simon, Nucleic acids research . 2010,第11期

机译：HIV-1整合酶的合作和特异性DNA结合模式取决于金属辅因子的性质，并涉及含锌的N末端结构域
4. DNA Length and Cationic Cofactor Dependent Strand Transfer Activity of HIV-1 Integrase [C] . Hong-qiu He, Cun-xin Wang, Wei-zu Chen Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009 . 2009

机译：HIV-1整合酶的DNA长度和阳离子辅因子依赖性链转移活性。
5. Catalytic carbozincation of diazoesters and development of probes for F-18 imaging based on rapid bioorthogonal reactivity. [D] . Selvaraj, Ramajeyam. 2014

机译：基于快速生物正交反应性的重氮酯催化碳氧合和F-18成像探针的开发。
6. Zinc folds the N-terminal domain of HIV-1 integrase promotes multimerization and enhances catalytic activity [O] . Ronglan Zheng, Timothy M. Jenkins, Robert Craigie 1996

机译：锌折叠HIV-1整合酶的N末端结构域促进多聚并增强催化活性
7. Insight into the Roles of the 140-149 Catalytic Loop and the Zinc-Binding Domain for HIV-1 Integrase Activity [O] . Carayon Kevin, Na Li, Delelis Olivier, 2009

机译：深入了解140-149催化环和锌结合域对HIV-1整合酶活性的作用

Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity

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