Interactions between two divalent ion binding sites in N-methyl-D-aspartate receptor channels

Geeta Sharma; Charles F. Stevens

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Interactions between two divalent ion binding sites in N-methyl-D-aspartate receptor channels

机译：N-甲基-D-天冬氨酸受体通道中两个二价离子结合位点之间的相互作用

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N-methyl-D-aspartate receptor channels ex- hibit a high permeability for calcium ions. In this report, we confirm that calcium ions permeate effectively through the wild-type channels, and find that their presence within the pore blocks the flux of sodium and other ions. Further proof for this ionic block comes from the analysis of the ε1(N614Q) mutation where the high permeability of calcium is unchanged but the block by calcium ions is increased twofold.

机译：N-甲基-D-天冬氨酸受体通道对钙离子具有高渗透性。在此报告中，我们确认钙离子有效地通过野生型通道渗透，并发现它们在孔中的存在会阻止钠和其他离子的通量。此离子阻滞的进一步证据来自对ε1（N614Q）突变的分析，其中钙的高渗透性不变，但钙离子阻滞增加了两倍。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第24期|p.14170-14175|共6页
作者
Geeta Sharma; Charles F. Stevens;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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6. Interactions between two divalent ion binding sites in N-methyl-d-aspartate receptor channels [O] . Geeta Sharma, Charles F. Stevens 1996

机译：两个二价离子结合位点之间的相互作用 N-甲基-d-天冬氨酸受体通道
7. Interactions between two divalent ion binding sites in N-methyl-D-aspartate receptor channels [O] . G. Sharma, C. F. Stevens 1996

机译：N-甲基-D-天冬氨酸受体通道两种二价离子结合位点之间的相互作用

Interactions between two divalent ion binding sites in N-methyl-D-aspartate receptor channels

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