Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying K~+ channel subunit

Kim W. Chan; Jin-Liang Sui; Michel Vivaudou

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Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying K~+ channel subunit

机译：通过G蛋白门控的内向整流K〜+通道亚基的独特氨基酸残基控制通道活性

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G protein-gated inwardly rectifying K~+ (GIRK) channels, which are important regulators of mem- brane excitability both in heart and brain, appear to function as heteromultimers. GIRK1 is unique in the GIRK channel family in that although it is by itself inactive, it can associate with the other family members (GIRK2-GIRK5) to enhance their activity and alter their single-channel characteristics. By generating a series of chimeras, we identified a phenylalanine residue, F137, in the pore region of GIRK1 that critically controls channel activity.

机译：G蛋白门控的内向整流K〜+（GIRK）通道，是心脏和大脑中膜兴奋性的重要调节剂，似乎起着异源多聚体的作用。 GIRK1在GIRK通道家族中是唯一的，尽管它本身并不活跃，但它可以与其他家族成员（GIRK2-GIRK5）关联以增强其活动性并改变其单通道特性。通过生成一系列嵌合体，我们在GIRK1的孔区域中发现了一个苯丙氨酸残基F137，该残基严格控制通道活性。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第24期|p.14193-14198|共6页
作者
Kim W. Chan; Jin-Liang Sui; Michel Vivaudou;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury [J] . Chuang Lyu, Gong-Wei Lyu, Jan Mulder, Journal of Pain Research . 2020,第1期

机译：在外周神经损伤后，在大鼠DRG和脊髓中上调G蛋白质门静置渗碳亚基3
2. G protein-gated inwardly rectifying potassium channel subunit 3 knock-out mice show enhanced ethanol reward (vol 40, pg 857, 2016) [J] . Tipps M. E., Raybuck J. D., Kozell L. B., Alcoholism: Clinical and experimental research . 2016,第10期

机译：G蛋白门控的内向整流钾通道亚基3基因敲除小鼠显示出更高的乙醇奖励（第40卷，第857页，2016年）
3. G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 Knock-Out Mice Show Enhanced Ethanol Reward [J] . Tipps Megan E., Raybuck Jonathan D., Kozell Laura B., Alcoholism: Clinical and experimental research . 2016,第4期

机译：G蛋白门控内向钾通道亚基3基因敲除小鼠显示增强的乙醇奖励。
4. FLOW SENSITIVITY OF INWARDLY-RECTIFYING K{sup}+ CHANNELS IN HUMAN AOTIC ENDOTHELIUM [C] . Yun Fang, Victor Romanenko, Peter F. Davies, IASTED International Conference on Biomechanics . 2005

机译：在人体美食内皮中向内整流k {sup} +通道的流动敏感性
5. Development of Molecular Tools for the Investigation of G protein-gated Inwardly Rectifying Potassium (GIRK) Channels. [D] . Ramos-Hunter, Susan Joanne. 2017

机译：用于研究G蛋白门控的内向整流钾（GIRK）通道的分子工具的开发。
6. Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying K+ channel subunit [O] . Kim W. Chan, Jin-Liang Sui, Michel Vivaudou, 1996

机译：通过独特的氨基酸残基控制通道活性 G蛋白门控的内向整流K +通道亚基
7. >G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury [O] . Chuang Lyu, Gong-Wei Lyu, Jan Mulder, 2020

机译：> g蛋白质偏转的向内整流钾通道亚基3在外周神经损伤后大鼠DRG和脊髓上调
8. Role of Mg(2+) in the Inactivation of Inwardly Rectifying K(+) Channels in AorticEndothelial Cells [R] . Elam, T. R., Lansman, J. B. 1995

机译：mg（2+）在主动脉内皮细胞内向整流K（+）通道失活中的作用

Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying K~+ channel subunit

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