Embryonic neuronal markers in tuberous sclerosis: Single-cell molecular pathology

Peter B. Crino; John Q. Trojanowski; Marc A. Dichter

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Embryonic neuronal markers in tuberous sclerosis: Single-cell molecular pathology

【24h】

Embryonic neuronal markers in tuberous sclerosis: Single-cell molecular pathology

机译：结节性硬化中的胚胎神经元标志物：单细胞分子病理学

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

One hallmark of tuberous sclerosis (TSC) is the presence of highly epileptogenic dysplastic cerebral cortex (tubers) composed of abnormally shaped neurons and giant cells. Mutation of the TSC gene (TSC2) may disrupt differ- entiation and maturation of neuronal precursors, since the TSC2 gene product tuberin is believed to regulate cellular proliferation. To test the hypothesis that cells in tubers may retain the molecular phenotype of embryonic or immature neurons, tubers from five TSC patients were probed with antibodies to proteins expressed in neuronal precursors (nes- tin, Ki-67, and proliferating cell nuclear antigen).

机译：结节性硬化症（TSC）的一个标志是存在高度致癫痫的发育异常的大脑皮层（块茎），由异常形状的神经元和巨细胞组成。 TSC基因（TSC2）的突变可能会破坏神经元前体的分化和成熟，因为TSC2基因产物tuberin被认为可以调节细胞增殖。为了检验以下假设，即块茎中的细胞可以保留胚胎或未成熟神经元的分子表型，对五名TSC患者的块茎进行了神经元前体（nestin，Ki-67和增殖性细胞核抗原）表达蛋白抗体的探测。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第24期|p.14152-14157|共6页
作者
Peter B. Crino; John Q. Trojanowski; Marc A. Dichter;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Molecular markers of neuronal progenitors in the embryonic cerebellar anlage. [J] . Morales D, Hatten ME The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2006,第47期

机译：胚胎小脑re神经元祖细胞的分子标记。
2. Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions. [J] . Magri L, Cambiaghi M, Cominelli M, Cell stem cell . 2011,第5期

机译：胚胎神经干细胞中mTOR通路的持续激活导致结节性硬化症相关病变的发展。
3. Neuronal spiking activity highlights a gradient of epileptogenicity in human tuberous sclerosis lesions [J] . Despouy Elodie, Curot Jonathan, Denuelle Marie, Clinical neurophysiology . 2019,第4期

机译：神经元尖刺活动突出了人肿块硬化病变中癫痫发生性的梯度
4. Machine Learning in Epilepsy Drug Treatment Outcome Prediction Using Multi-modality Data in Children with Tuberous Sclerosis Complex [C] . Jun Yang, Cailei Zhao, Shi Su, International Conference on Big Data and Information Analytics . 2020

机译：机器学习在癫痫药物治疗结果预测中使用肿瘤硬化复合体儿童的多种形态数据预测
5. The quest for a myelin specific magnetic resonance marker of multiple sclerosis pathology: Myelin water imaging. [D] . Laule, Cornelia. 2005

机译：对多发性硬化症病理的髓磷脂特异性磁共振标记物的追求：髓磷脂水成像。
6. Embryonic neuronal markers in tuberous sclerosis: Single-cell molecular pathology [O] . Peter B. Crino, John Q. Trojanowski, Marc A. Dichter, 1996

机译：结节性硬化中的胚胎神经元标志物：单细胞分子病理学
7. Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model [O] . Nils Grabole, Jitao David Zhang, Stefan Aigner, 2016

机译：人类干细胞模型对结节性硬化分子神经病理学的基因组分析

Embryonic neuronal markers in tuberous sclerosis: Single-cell molecular pathology

摘要

著录项

相似文献

相关主题

期刊订阅