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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo
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Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo

机译:干扰素诱导蛋白10被确定为体内肿瘤坏死的介质

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摘要

Human Burkitt lymphoma cell lines give rise to progressively growing subcutaneous tumors in athymic mice. These tumors are induced to regress by inoculation of Epstein-Barr virus-immortalized normal human lympho- cytes. In the present study, analysis of profiles of murine cytokine/chemokine gene expression in Burkitt tumor tissues excised from the nude mice showed that expression of the murine -chemokine interferon-inducible protein-10 (IP-10) was higher in the regressing than in the progressive Burkitt tumors. We tested the effects of IP-10 on Burkitt tumor growth in nude mice.
机译:人伯基特淋巴瘤细胞系在无胸腺小鼠中引起逐渐生长的皮下肿瘤。通过接种爱泼斯坦-巴尔病毒永生化的正常人淋巴细胞可以诱导这些肿瘤消退。在本研究中,从裸鼠切除的Burkitt肿瘤组织中鼠细胞因子/趋化因子基因表达的概况分析表明,鼠趋化因子干扰素诱导蛋白10(IP-10)的表达在回归中高于在小鼠中。进行性Burkitt肿瘤。我们测试了IP-10对裸鼠Burkitt肿瘤生长的影响。

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