Intrastriatally injected c-fos antisense oligonucleotide interferes with striatonigral but not striatopallidal γ-aminobutyric acid transmission in the conscious rat

W. Sommer; R. Rimondini; W. OConnor

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Intrastriatally injected c-fos antisense oligonucleotide interferes with striatonigral but not striatopallidal γ-aminobutyric acid transmission in the conscious rat

机译：纹状体内注射c-fos反义寡核苷酸可干扰意识大鼠的纹状体的产生，但不会干扰纹状体中的γ-氨基丁酸传递

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Antisense c-fos oligonucleotides injected into the neostriatum of conscious rats selectively inhibited c-fos expression associated with compensatory increases in striatal c-fos mRNA levels and also with increased expression of junB and NGFI-A mRNA, probably as a result of regulatory phe- nomena. Dual probe in vivo microdialysis was used to inves- tigate γ-aminobutyric acid (GABA) release in the substantia nigra and the globus pallidus, which represent the terminal sites of the dopamine D1 receptor regulated striatonigral and the dopamine D2 receptor regulated striatopallidal GABA pathways, respectively.

机译：注入有意识大鼠新纹状体的反义c-fos寡核苷酸选择性抑制c-fos表达，这与纹状体c-fos mRNA水平的补偿性增加以及junB和NGFI-A mRNA的表达增加有关，这可能是由于phe-命名。采用双探针体内微透析法研究了黑质和苍白球中的γ-氨基丁酸（GABA）释放，它们代表了多巴胺D1受体调节的纹状体神经的末端位点，以及多巴胺D2受体调节的纹状体的GABA途径，分别。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第24期|p.14134-14139|共6页
作者
W. Sommer; R. Rimondini; W. OConnor;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Amphetamine-induced Fos expression is evident in gamma-aminobutyric acid neurons in the globus pallidus and entopeduncular nucleus in rats treated with intrastriatal c-fos antisense oligodeoxynucleotides. [J] . Ishida Yasushi, Denovan Wright Eileen, Hebb MatthewO, Experimental Neurology . 2002,第1期

机译：在纹状体内c-fos反义寡脱氧核苷酸治疗的大鼠中，苍白球和上皮下核中的γ-氨基丁酸神经元中有明显的苯丙胺诱导的Fos表达。
2. Continuous administration of antisense oligonucleotides to c-fos reduced the development of seizure susceptibility after ethacrynic acid-induced seizure in mice. [J] . Suzukawa J, Omori K, Yang L, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2003,第1期

机译：连续向c-fos施用反义寡核苷酸可减少乙炔酸诱导的小鼠癫痫发作后癫痫发作敏感性的发展。
3. Enhanced striatopallidal gamma‐aminobutyric acid (GABA) A A receptor transmission in mouse models of huntington's disease [J] . Perez‐Rosello Tamara, Gelman Simon, Tombaugh Geoffrey, Movement disorders . 2019,第5期

机译：增强的纹状体γ-氨基丁酸（GABA）亨廷顿疾病小鼠模型中的受体传播
4. Cellular Dynamics of Antisense Oligonucleotides and Short Interfering RNAs [C] . LI KIM LEE, BRANDEE M.DUNHAM, ZHUTING LI, Oligonucleotide Therapeutics Society . 2006

机译：反义寡核苷酸细胞动力学和短干扰RNA
5. Modulation of gamma-aminobutyric acid (GABA) type A receptor-mediated responses in spinal dorsal horn neurons by mu-opioid receptor agonists and calcium(2+)/calmodulin-dependent protein kinase and Monte Carlo simulation of the GABAergic synaptic transmission. [D] . Wang, Rong. 1995

机译：γ-氨基丁酸（GABA）A型受体介导的mu阿片类受体激动剂和钙（2 +）/钙调蛋白依赖性蛋白激酶和Monte Carlo模拟的GABA能突触传递的脊髓背角神经元。
6. Intrastriatally injected c-fos antisense oligonucleotide interferes with striatonigral but not striatopallidal γ-aminobutyric acid transmission in the conscious rat [O] . W. Sommer, R. Rimondini, W. O’Connor, 1996

机译：腹腔注射c-fos反义寡核苷酸干扰纹状体刺激但不干扰纹状体 γ-氨基丁酸在有意识大鼠体内的传播
7. Spherical Nucleic Acids for Near-Infrared Light-Responsive Self-Delivery of Small-Interfering RNA and Antisense Oligonucleotide [O] . -1

机译：用于近红外光响应的球形核酸的小干扰RNA和反义寡核苷酸

Intrastriatally injected c-fos antisense oligonucleotide interferes with striatonigral but not striatopallidal γ-aminobutyric acid transmission in the conscious rat

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