Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A deg resolution

Travis Stams; Satish K. Nair; Torayuki Okuyama

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Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A deg resolution

机译：膜相关的人类碳酸酐酶IV分泌形式的晶体结构，分辨率为2.8-A

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It has recently been demonstrated that the C-terminal deletion mutant of recombinant human carbonic anhydrase IV (G267X CA IV) converts the normally glyco- sylphosphatidylinositol-anchored enzyme into a soluble se- cretory form which has the same catalytic properties as the membrane-associated enzyme purified from human tissues. We have determined the three-dimensional structure of the secretory form of human CA IV by x-ray crystallographic methods to a resolution of 2.8 A deg.

机译：最近已证明，重组人碳酸酐酶IV（G267X CA IV）的C端缺失突变体可将正常的糖基磷脂酰肌醇固定的酶转化为可溶的分泌形式，其催化特性与膜相关的相同。从人体组织中纯化的酶。我们已经通过X射线晶体学方法确定了人CA IV分泌形式的三维结构，分辨率为2.8 A度。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第24期|p.13589-13594|共6页
作者
Travis Stams; Satish K. Nair; Torayuki Okuyama;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. In silico study on the carbonic anhydrase activators : Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines [J] . Singh Shalini Journal of the Indian Chemical Society . 2015,第2期

机译：在计算机上研究碳酸酐酶激活剂：氨基酸和胺类激活人胞质同工酶III和膜相关同工型IV
2. Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines. [J] . Vullo D, Nishimori I, Scozzafava A, Bioorganic and Medicinal Chemistry Letters . 2008,第15期

机译：碳酸酐酶激活剂：用氨基酸和胺激活人胞质同工酶III和膜相关同工型IV。
3. Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines. [J] . Vullo D, Nishimori I, Scozzafava A, Bioorganic and Medicinal Chemistry Letters . 2008,第15期

机译：碳酸酐酶激活剂：用氨基酸和胺激活人胞质同工酶III和膜相关同工型IV。
4. Modelling the Inhibition Activity on Carbonic Anhydrase I of Some Substituted Thiadiazole- and Thiadiazoline- Disulfonamides: Integration of Structure Information [C] . Sorana-Daniela Bolboaca, Lorentz Jantschi European Symposium on Computer Aided Process Engineering . 2006

机译：一些取代的噻二唑和噻二唑啉 - 二硫胺碳酸酐酶I对抑制活性的抑制活性：结构信息的整合
5. Structure and catalysis at the active site of human carbonic anhydrase II. [D] . Avvaru, Balendu Sankara. 2010

机译：人碳酸酐酶II活性位点的结构和催化作用。
6. Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-Å resolution [O] . Travis Stams, Satish K. Nair, Torayuki Okuyama, 1996

机译：晶体结构与膜相关的分泌形式人类碳酸酐酶IV分辨率为2.8
7. Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-Å resolution [O] . Stams, Travis, Nair, Satish K., Okuyama, Torayuki, 1996

机译：晶体结构与膜相关的分泌形式人类碳酸酐酶IV分辨率为2.8
8. Dynamic (13)C NMR Studies on the Active Site Structure and Kinetics of Human Carbonic Anhydrase I [R] . Henkens, R. W., Merrill, S. P., Williams, T. J. 1984

机译：动态（13）C NmR研究人碳酸酐酶的活性位点结构和动力学I.

Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A deg resolution

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