Gly-63 - Gln substitution adjacent to His-64 in rodent carbonic anhydrase IVs largely explains their reduced activity

Shinya Tamai; Abdul Waheed; Lee B. Cody

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Gly-63 - Gln substitution adjacent to His-64 in rodent carbonic anhydrase IVs largely explains their reduced activity

机译：Gly-63-在啮齿动物碳酸酐酶IV中与His-64相邻的Gln取代在很大程度上解释了它们的活性降低

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Carbonic anhydrase (CA) IV is a glycosyl- phosphatidylinositol-anchored isozyme expressed on plasma membranes of capillary endothelial cells and certain epithe- lial cells of the nephron, the colon, and the genitourinary tract. CA IVs purified from bovine and rabbit lungs are high-activity enzymes, like human CA IV, while CA IV from mouse and rat lungs had only 10-20/100 as much catalytic activity. To explain the molecular basis for these differences in activity, we isolated and characterized the full-length cDNAs for bovine and rabbit CA IVs and compared their sequences to those we previously reported for human, murine, and rat CA IVs.

机译：碳酸酐酶（CA）IV是在毛细血管内皮细胞和肾，结肠和泌尿生殖道的某些上皮细胞的质膜上表达的糖基磷脂酰肌醇固定的同工酶。从牛和兔肺中提纯的CA IVs是高活性酶，就像人CA IV一样，而从小鼠和大鼠肺中提取的CA IV的催化活性仅为10-20 / 100。为解释这些活性差异的分子基础，我们分离并鉴定了牛和兔CA IV的全长cDNA，并将它们的序列与我们先前报道的人，鼠和大鼠CA IV的序列进行了比较。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第24期|p.13647-13652|共6页
作者
Shinya Tamai; Abdul Waheed; Lee B. Cody;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. [J] . Smaine FZ, Pacchiano F, Rami M, Bioorganic and Medicinal Chemistry Letters . 2008,第24期

机译：碳酸酐酶抑制剂：2-取代的1,3,4-噻二唑-5-磺酰胺可作为线粒体同工酶VA和VB的强力和选择性抑制剂，作用于胞质和膜相关的碳酸酐酶I，II和IV。
2. Transport Activity of the High-affinity Monocarboxylate Transporter MCT2 Is Enhanced by Extracellular Carbonic Anhydrase IV but Not by Intracellular Carbonic Anhydrase II [J] . Michael Klier, Christina Schüler, Andrew P. Halestrap, The Journal of biological chemistry . 2011,第31期

机译：通过细胞外碳酸酐酶IV而不是通过细胞内碳酸酐酶II来增强高亲和力单羧酸盐转运蛋白转运蛋白MCT2的运输活性
3. Mutation of active site residues Asn67 to Ile, Gln92 to Val and Leu204 to ser in human carbonic anhydrase II: Influences on the catalytic activity and affinity for inhibitors [J] . TurkogluS., MarescaA., AlperM., Bioorganic and medicinal chemistry . 2012,第7期

机译：活性位点残基Asn67突变为Ile，Gln92突变为Val和Leu204突变为人碳酸酐酶II：对催化活性和抑制剂亲和力的影响
4. Modelling the Inhibition Activity on Carbonic Anhydrase I of Some Substituted Thiadiazole- and Thiadiazoline- Disulfonamides: Integration of Structure Information [C] . Sorana-Daniela Bolboaca, Lorentz Jantschi European Symposium on Computer Aided Process Engineering . 2006

机译：一些取代的噻二唑和噻二唑啉 - 二硫胺碳酸酐酶I对抑制活性的抑制活性：结构信息的整合
5. Assessing the Competitive Advantage of Carbonic Anhydrase in Estuarine Microalgae Through Removed Enzymatic Activity [D] . Knotts, Eilea R. 2019

机译：通过除去酶活性评估碳酸酐酸碳酸酐酶的竞争优势
6. Gly-63 → Gln substitution adjacent to His-64 in rodent carbonic anhydrase IVs largely explains their reduced activity [O] . Shinya Tamai, Abdul Waheed, Lee B. Cody, 1996

机译：啮齿类动物碳中Gly-63→与His-64相邻的Gln取代酸酐酶IV很大程度上解释了它们的活性降低
7. Gly-63 -> Gln substitution adjacent to His-64 in rodent carbonic anhydrase IVs largely explains their reduced activity [O] . S. Tamai, A. Waheed, L. B. Cody, 1996

机译：Gly-63 - >在啮齿动物碳酸酐酶IV中邻近His-64的Gln取代在很大程度上解释了它们减少的活性

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Gly-63 - Gln substitution adjacent to His-64 in rodent carbonic anhydrase IVs largely explains their reduced activity

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