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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
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Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells

机译:瘦素可诱导造血细胞增殖,分化和功能激活

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摘要

Many cytokines exert their biological effect through members of the hemopoietin receptor family. Using degenerate oligonucleotides to the common WSXWS motif, we have cloned from human hemopoietic cell cDNA libraries various forms of the receptor that was recently shown to bind the obesity hormone, leptin. mRNAs encoding long and short forms of the human leptin receptor were found to be coex- ressed in a range of human and murine hemopoietic organs, and a subset of cells from these tissues bound leptin at the cell surface.
机译:许多细胞因子通过造血素受体家族的成员发挥其生物学作用。使用简并的​​寡核苷酸至常见的WSXWS基序,我们从人造血细胞cDNA文库中克隆了各种形式的受体,该受体最近被证明与肥胖激素瘦素结合。发现编码人类瘦素受体长短形式的mRNA在一系列人类和鼠类造血器官中共存,来自这些组织的一部分细胞在细胞表面结合了瘦素。

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