Immune response to a differentiation antigen induced by altered antigen: A study of tumor rejection and autoimmunity

Clarissa Naftzger; Yoshizumi Takechi; Hironobu Kohda

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Immune response to a differentiation antigen induced by altered antigen: A study of tumor rejection and autoimmunity

机译：改变抗原诱导的分化抗原的免疫反应：肿瘤排斥和自身免疫的研究

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Recognition of self is emerging as a theme for the immune recognition of human cancer. One question is whether the immune system can actively respond to normal tissue autoantigens expressed by cancer cells. A second but related question is whether immune recognition of tissue autoantigens can actually induce tumor rejection. To address these issues, a mouse model was developed to investigate immune responses to a melanocyte differentiation antigen, tyrosinase-related protein 1 (or gp75), which is the product of the brown locus.

机译：自我识别正在成为免疫识别人类癌症的主题。一个问题是免疫系统是否可以对癌细胞表达的正常组织自身抗原产生积极反应。第二个但相关的问题是组织自身抗原的免疫识别是否实际上可以诱导肿瘤排斥。为了解决这些问题，开发了一种小鼠模型来研究对黑色素细胞分化抗原酪氨酸酶相关蛋白1（或gp75）的免疫反应，该蛋白是棕色基因座的产物。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第25期|p.14809-14814|共6页
作者
Clarissa Naftzger; Yoshizumi Takechi; Hironobu Kohda;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. Tumor-secific immunity to chemically induced tumors. Evidence for immunologic specificity and shared antigenicity in lymphocyte responses to soluble tumor antigens. [J] . J T Frbes, Y Nakaw, R T Smith The Journal of Experomental Medicine . 1975,第5期

机译：对化学诱导肿瘤的肿瘤特异性免疫。淋巴细胞对可溶性肿瘤抗原的免疫特异性和共有抗原性的证据。
2. Coexpression of GM-CSF and antigen in DNA prime-adenoviral vector boost immunization enhances polyfunctional CD8+ T cell responses, whereas expression of GM-CSF antigen fusion protein induces autoimmunity [J] . Matthias Tenbusch, Seraphin Kuate, Bettina Tippler, BMC Immunology . 2008,第1期

机译：GM-CSF和抗原在DNA初级腺病毒载体加强免疫中的共表达增强了多功能CD8 + T细胞的应答，而GM-CSF抗原融合蛋白的表达诱导了自身免疫
3. Antihuman leukocyte antigen antibody-induced autoimmunity: role in chronic rejection. [J] . Nath DS, Basha HI, Mohanakumar T Current opinion in organ transplantation . 2010,第1期

机译：抗人白细胞抗原抗体诱导的自身免疫：在慢性排斥反应中的作用。
4. Probing Antigen Recognition of Effector T Cells in Anti-Tumor Immune Responses [C] . Beth Pearce, C. Garrett Rappazzo, Kelly Moynihan, Protein Engineering Summit. . 2018

机译：抗原免疫应答效应T细胞的抗原识别
5. I: Delivery of Carbohydrate Antigens by Glycopolymers as Potential Anti-cancer Vaccines; II: A Study of the Impacts of Valency and Density on Immune Response Against a Tumor Associated Carbohydrate Antigen [D] . Qin, Qian 2019

机译：I：糖聚合物作为潜在的抗癌疫苗传递碳水化合物抗原； II：价和密度对针对肿瘤相关碳水化合物抗原的免疫反应的影响的研究
6. Immune response to a differentiation antigen induced by altered antigen: A study of tumor rejection and autoimmunity [O] . Clarissa Naftzger, Yoshizumi Takechi, Hironobu Kohda, 1996

机译：改变引起的对分化抗原的免疫反应抗原：肿瘤排斥和自身免疫研究
7. Immune response to a differentiation antigen induced by altered antigen: A study of tumor rejection and autoimmunity [O] . C. Naftzger, Y. Takechi, H. Kohda, 1996

机译：对改变抗原诱导的分化抗原的免疫应答：肿瘤排斥和自身免疫的研究
8. Identification of Breast Tumor Antigens Targeted by the Immune Response during Tumor Rejection [R] . Knutson, K. L. 2004

机译：肿瘤排斥反应中免疫应答靶向乳腺肿瘤抗原的鉴定

Immune response to a differentiation antigen induced by altered antigen: A study of tumor rejection and autoimmunity

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