Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis

Lisa M. Landino; Brenda C. Crews; Michael D. Timmons

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Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis

机译：一氧化氮和一氧化氮的偶联产物过氧亚硝酸盐可激活前列腺素的生物合成

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Peroxynitrite activates the cyclooxygenase activities of constitutive and inducible prostaglandin endo- peroxide synthases by serving as a substrate for the enzymes' peroxidase activities. Activation of purified enzyme is induced by direct addition of peroxynitrite or by in situ generation of peroxynitrite from NO coupling to superoxide anion. Cu,Zn- superoxide dismutase completely inhibits cyclooxygenase ac- tivation in systems where peroxynitrite is generated in situ from superoxide.

机译：过氧亚硝酸盐通过充当酶的过氧化物酶活性的底物来激活组成型和诱导型前列腺素内过氧化物合酶的环氧合酶活性。通过直接添加过氧亚硝酸盐或通过从NO偶联到超氧阴离子的原位生成过氧亚硝酸盐来诱导纯化的酶的活化。在由超氧化物原位生成过氧亚硝酸盐的系统中，Cu，Zn-超氧化物歧化酶完全抑制了环氧合酶的活化。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第26期|p.15069-15074|共6页
作者
Lisa M. Landino; Brenda C. Crews; Michael D. Timmons;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Endogenous nitric oxide activates prostaglandin F2 alpha production in human microglial cells but not in astrocytes: a study of interactions between eicosanoids, nitric oxide, and superoxide anion (O2-) regulatory pathways. [J] . Janabi N, Chabrier S, Tardieu M The Journal of Immunology: Official Journal of the American Association of Immunologists . 1996,第5期

机译：内源性一氧化氮激活人小神经胶质细胞而不是星形胶质细胞中前列腺素F2α的产生：类花生酸，一氧化氮和超氧阴离子（O2-）调节途径之间相互作用的研究。
2. Endogenous nitric oxide activates prostaglandin F2 alpha production in human microglial cells but not in astrocytes: a study of interactions between eicosanoids, nitric oxide, and superoxide anion (O2-) regulatory pathways. [J] . N Janabi, S Chabrier, M Tardieu The journal of immunology . 1996,第5期

机译：内源性一氧化氮激活人小神经胶质细胞而不是星形胶质细胞中前列腺素F2α的产生：类花生酸，一氧化氮和超氧阴离子（O2-）调节途径之间相互作用的研究。
3. Endogenous nitric oxide activates prostaglandin F2 alpha production in human microglial cells but not in astrocytes: a study of interactions between eicosanoids, nitric oxide, and superoxide anion (O2-) regulatory pathways. [J] . N Janabi, S Chabrier, M Tardieu The journal of immunology . 1996,第5期

机译：内源性一氧化氮激活人小神经胶质细胞而不是星形胶质细胞中前列腺素F2α的产生：类花生酸，一氧化氮和超氧阴离子（O2-）调节途径之间相互作用的研究。
4. Impact of Superoxide Dismutase on Nitric Oxide and Peroxynitrite Levels in the Microcirculation - A Computational Model [C] . Chavez, M.D., Lakshmanan, Engineering in Medicine and Biology Society, 2007 Annual International Conference of the IEEE . 2007

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5. The roles of peroxynitrite and superoxide in oxidative damage to E. coli. [D] . Opperman, Kay Keyer. 1997

机译：过氧亚硝酸盐和超氧化物在对大肠杆菌的氧化损伤中的作用。
6. Peroxynitrite the coupling product of nitric oxide and superoxide activates prostaglandin biosynthesis [O] . Lisa M. Landino, Brenda C. Crews, Michael D. Timmons, 1996

机译：过氧亚硝酸盐一氧化氮与超氧化物激活前列腺素的生物合成
7. Peroxynitrite, a product between nitric oxide and superoxide anion, plays a cytotoxic role in the development of post-bypass systemic inflammatory response☆ [O] . Yoshitaka Hayashi, Yoshiki Sawa, Motonobu Nishimura, 2004

机译：过氧化物，一氧化氮和超氧化物阴离子之间的产物在旁路后系统炎症反应的发育中发挥了细胞毒性作用☆

Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis

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