Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas

Marian A. J. Weterman; Monique Wilbrink; Ad Geurts van Kessel

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Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas

机译：T（X; 1）（p11; q21）阳性乳头状肾细胞癌中转录因子TFE3基因与新型基因PRCC的融合

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The (X;1)(p11;q21) translocation is a recur- rent chromosomal abnormality in a subset of human papillary renal cell carcinomas, and is sometimes the sole cytogenetic abnormality present. Via positional cloning, we were able to identify the genes involved. The translocation results in a fusion of the transcription factor TFE3 gene on the X chro- mosome to a novel gene, designated PRCC, on chromosome 1. Through this fusion, reciprocal translocation products are formed, which are both expressed in papillary renal cell carcinomas.

机译：（X; 1）（p11; q21）易位是人类乳头状肾细胞癌的一个子集中的复发性染色体异常，有时是唯一的细胞遗传学异常。通过位置克隆，我们能够鉴定涉及的基因。易位导致X染色体上的转录因子TFE3基因与1号染色体上的新基因PRCC融合。通过这种融合，形成了相互易位的产物，它们均在乳头状肾细胞癌中表达。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第26期|p.15294-15298|共5页
作者
Marian A. J. Weterman; Monique Wilbrink; Ad Geurts van Kessel;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：与XP11.2易位/ TFE3基因融合相关的成人肾细胞癌的对比增强超声检查：与透明细胞肾细胞癌和乳头肾细胞癌的比较
2. MDCT Findings of Renal Cell Carcinoma Associated With Xp11.2 Translocation and TFE3 Gene Fusion and Papillary Renal Cell Carcinoma [J] . Woo Sungmin, Kim Sang Youn, Lee Myoung Seok, AJR: American Journal of Roentgenology : Including Diagnostic Radiology, Radiation Oncology, Nuclear Medicine, Ultrasonography and Related Basic Sciences . 2015,第3期

机译：Xp11.2易位和TFE3基因融合与乳头状肾细胞癌相关的肾细胞癌的MDCT发现
3. Novel gene fusion of PRCC–MITF PRCC–MITF defines a new member of MiT family translocation renal cell carcinoma: clinicopathological analysis and detection of the gene fusion by RNA sequencing and FISH [J] . Xia Qiu‐Yuan, Wang Xiao‐Tong, Ye Sheng‐Bing, Histopathology: Official Journal of the British Division of the International Academy of Pathology . 2018,第5期

机译：PRCC-MITF的新型基因融合PRCC-MITF定义了MIT家族易位肾细胞癌的新成员：RNA测序和鱼类的临床病理分析和检测基因融合
4. Application of High-Throughput Sequencing Data Mining in Comparison of Gene Expression Profile in Renal Cell Carcinoma and Normal Renal Cell by RNA-Seq [C] . Yunhai Yu, Hongmei Xu, Shaoning Guo, International Conference on Innovative Computing . 2020

机译：高通量测序数据挖掘在RNA-SEQ肾细胞癌和正常肾细胞中基因表达谱的比较中的应用
5. Understanding the Attributes of Papillary Renal Cell Carcinoma subtypes: Molecular Analysis, Biomarker Discovery and Implications to Therapy [D] . Saleeb, Rola Magdy Yousef. 2018

机译：了解乳头状肾细胞癌亚型的属性：分子分析，生物标志物发现及其对治疗的意义
6. Fusion of the transcription factor TFE3 gene to a novel gene PRCC in t(X;1)(p11;q21)-positive papillary renal cell carcinomas [O] . Marian A. J. Weterman, Monique Wilbrink, Ad Geurts van Kessel 1996

机译：转录因子融合 TFE3基因变成一个新基因 PRCC在t（X; 1）（p11; q21）阳性乳头中肾细胞癌
7. Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas [O] . Weterman, M. A., Wilbrink, M., Geurts van Kessel, A. 1996

机译：T（X; 1）（p11; q21）阳性乳头状肾细胞癌中转录因子TFE3基因与新型基因PRCC的融合

Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas

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