Effect of β-amyloid block of the fast-inactivating K~+ channel on intracellular Ca~2+ and excitability in a modeled neuron

Theresa A. Good; Regina M. Murphy

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Effect of β-amyloid block of the fast-inactivating K~+ channel on intracellular Ca~2+ and excitability in a modeled neuron

机译：快速失活的K〜+通道的β淀粉样蛋白阻滞对模拟神经元细胞内Ca〜2 +和兴奋性的影响

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β-Amyloid peptide (Aβ), one of the primary protein components of senile plaques found in Alzheimer disease, is believed to be toxic to neurons by a mechanism that may involve loss of intracellular calcium regulation. We have previously shown that Aβ blocks the fast-inactivating potas- sium (A) current. In this work, we show, through the use of a mathematical model, that the Aβ-mediated block of the A current could result in increased intracellular calcium levels and increased membrane excitability, both of which have been observed in vitro upon acute exposure to Aβ.

机译：β-淀粉样肽（Aβ）是阿尔茨海默病中发现的老年斑的主要蛋白质成分之一，据信可能通过涉及细胞内钙调节丧失的机制对神经元具有毒性。先前我们已经证明Aβ阻止了快速灭活的钾（A）电流。在这项工作中，我们显示通过使用数学模型，Aβ介导的A电流阻滞可能导致细胞内钙水平增加和膜兴奋性增加，这在急性暴露于Aβ的体外均已观察到。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第26期|p.15130-15135|共6页
作者
Theresa A. Good; Regina M. Murphy;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Amyloid β Oligomers Increase ER-Mitochondria Ca 2+ Cross Talk in Young Hippocampal Neurons and Exacerbate Aging-Induced Intracellular Ca 2+ Remodeling [J] . Maria Calvo-Rodriguez, Elena Hernando-Perez, Lucia Nu?ez, Frontiers in Cellular Neuroscience . 2019,第2012期

机译：淀粉样β寡聚体增加年轻海马神经元的ER线粒体Ca 2 + 串扰，并加剧衰老诱导的细胞内Ca 2 + 重塑
2. Effects of amyloid beta-peptide fragment 31-35 on the BK channel-mediated K~+ current and intracellular free Ca~(2+) concentration of hippocampal CA1 neurons [J] . Yu Zhang, Zhi-Gang Shi, Zhi-Hua Wang, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2014,第Null期

机译：淀粉样蛋白β肽片段31-35对BK通道介导的K〜+电流和海马CA1神经元细胞内游离Ca〜（2+）浓度的影响
3. Effects of amyloid beta-peptide fragment 31-35 on the BK channel-mediated K~+ current and intracellular free Ca~(2+) concentration of hippocampal CA1 neurons [J] . Yu Zhang, Zhi-Gang Shi, Zhi-Hua Wang, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2014,第Null期

机译：淀粉样蛋白β肽片段31-35对BK通道介导的K〜+电流和海马CA1神经元细胞内游离Ca〜（2+）浓度的影响
4. The role of Ca/sup 2+/-channel blockers in the transition from ventricular fibrillation to ventricular tachycardia in an anatomical model of the human ventricles: a simulation study [C] . Bernus, O., Verschelde, Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE . 2003

机译：Ca / sup 2 +/-通道阻滞剂在人心室解剖模型中从心室纤颤向心动过速过渡的作用：模拟研究
5. A study of the effects of protease activated receptor-2 (PAR(2)) activation on neuronal excitability and underlying ion channels in mouse colonic dorsal root ganglia neurons [D] . Kayssi, Ahmed 2005

机译：蛋白酶激活受体2（PAR（2））激活对小鼠结肠背根神经节神经元神经元兴奋性和潜在离子通道的影响的研究。
6. Effect of β-amyloid block of the fast-inactivating K+ channel on intracellular Ca2+ and excitability in a modeled neuron [O] . Theresa A. Good, Regina M. Murphy 1996

机译：β淀粉样蛋白阻滞剂的快速灭活作用细胞内Ca2 +和模拟神经元的兴奋性
7. Beta-amyloid peptide blocks the fast-inactivating K+ current in rat hippocampal neurons. [O] . Good, T A, Smith, D O, Murphy, R M 1996

机译：β-淀粉样蛋白肽阻断大鼠海马神经元中快速灭活的K +电流。

Effect of β-amyloid block of the fast-inactivating K~+ channel on intracellular Ca~2+ and excitability in a modeled neuron

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