Homocysteine induces congenital defects of the heart and neural tube: Effect of folic acid

Thomas H. Rosenquist; S. Anne Ratashak; Jacob Selhub

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Homocysteine induces congenital defects of the heart and neural tube: Effect of folic acid

机译：同型半胱氨酸诱发心脏和神经管的先天性缺陷：叶酸的作用

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The biological basis or mechanism whereby folate supplementation protects against heart and neural tube defects is unknown. It has been hypothesized that the amino acid homocysteine may be the teratogenic agent, since serum homocysteine increases in folate depletion; however, this hypothesis has not been tested. In this study, avian embryos were treated directly with D,L-homocysteine or with L- homocysteine thiolactone, and a dose response was estab- lished.

机译：叶酸补充剂预防心脏和神经管缺陷的生物学基础或机理尚不清楚。据推测，氨基酸高半胱氨酸可能是致畸剂，因为血清高半胱氨酸会增加叶酸的消耗。但是，这一假设尚未得到检验。在这项研究中，直接用D，L-高半胱氨酸或L-高半胱氨酸硫代内酯处理禽类胚胎，并确定剂量反应。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第26期|p.15227-15232|共6页
作者
Thomas H. Rosenquist; S. Anne Ratashak; Jacob Selhub;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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2. Formate Supplementation May Prevent Some Neural Tube Defects that Prove Resistant to Folic Acid: Supplementation with formate rescued normal neural tube closure in more than three quarters of the embryos of novel folic acid‐resistant neural tube defect mouse models [J] . American journal of medical genetics, Part A . 2018,第8期

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3. Comment on changes in sex ratio in neural tube defects since food fortification with folic acid: Re "hypothesis: The female excess in cranial neural tube defects reflects an epigenetic drag of the inactivating X chromosome on the molecular mechanisms of neural tube fold elevation" [J] . EvansJ.A. Birth defects research, Part A. Clinical and molecular teratology . 2012,第11期

机译：自从用叶酸强化食物后，神经管缺陷的性别比例变化评论：关于“假说：颅神经管缺陷的女性过多反映了失活的X染色体对神经管皱折抬高的分子机制的表观遗传阻力”
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机译：3D明胶/壳聚糖支架内的GSK3 / Wnt信号分子的时间调控促进羊水衍生的诱导多能干细胞的心脏分化，用于先天性心脏缺陷修复
5. Genetic and phenotypic response of neural tube defect mouse mutants to folic acid. [D] . Nakouzi, Ghunwa A. 2009

机译：神经管缺陷小鼠突变体对叶酸的遗传和表型反应。
6. Homocysteine induces congenital defects of the heart and neural tube: Effect of folic acid [O] . Thomas H. Rosenquist, S. Anne Ratashak, Jacob Selhub 1996

机译：同型半胱氨酸诱发心脏的先天性缺陷和神经管：叶酸的作用
7. Homocysteine induces congenital defects of the heart and neural tube: Effect of folic acid [O] . T. H. Rosenquist, S. A. Ratashak, J. Selhub 1996

机译：同性冬氨酸诱导心脏和神经管的先天性缺陷：叶酸的作用

Homocysteine induces congenital defects of the heart and neural tube: Effect of folic acid

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