Mutation rate varies among alleles at a microsatellite locus: Phylogenetic evidence

Li Jin Claudia Macaubas; Joachim Hallmayer

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Mutation rate varies among alleles at a microsatellite locus: Phylogenetic evidence

机译：微卫星基因座上等位基因的突变率各不相同：系统发生学证据

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The understanding of the mutational mech- nism that generates high levels of variation at microsatellite loci lags far behind the application of these genetic markers. A phylogenetic approach was developed to study the pattern and rate of mutations at a dinucleotide microsatellite locus tightly linked to HLA-DQB1 (DQCAR). A random Japanese population (n = 129) and a collection of multiethnic samples (n = 941) were typed at the DQB1 and DQCAR loci. The phylogeny of DQB1 alleles was then reconstructed and DQ- AR alleles were superimposed onto the phylogeny.

机译：对在微卫星基因座上产生高水平变异的突变机制的理解远远落后于这些遗传标记的应用。开发了一种系统进化方法来研究与HLA-DQB1（DQCAR）紧密相连的二核苷酸微卫星基因座的突变模式和速率。在DQB1和DQCAR位点输入了一个随机的日本人口（n = 129）和一组多种族样本（n = 941）。然后重建DQB1等位基因的系统发育，并将DQ-AR等位基因叠加到系统发育上。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第26期|p.15285-15288|共4页
作者
Li Jin Claudia Macaubas; Joachim Hallmayer;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Differential patterns of spatial divergence in microsatellite and allozyme alleles: further evidence for locus-specific selection in the acorn barnacle, Semibalanus balanoides? [J] . Dufresne F., Bourget E., Bernatchez L. Molecular ecology . 2002,第1期

机译：微卫星和同工酶等位基因中空间差异的差异模式：进一步的证据表明橡子藤壶（Semibalanus balanoides）中的基因座特异性选择？
2. Single-locus tests of microsatellite evolution: multi-step mutations and constraints on allele size. [J] . Nielsen R, Palsbll PJ Molecular phylogenetics and evolution . 1999,第3期

机译：微卫星进化的单基因座测试：多步突变和等位基因大小的限制。
3. Mendelian Inheritance Pattern and High Mutation Rates of Microsatellite Alleles in the Diatom Pseudo-nitzschia multistriata [J] . Tesson S.V.M., Legrand C., van Oosterhout C., Protist . 2013,第1期

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4. Novel alleles at the Gli-Bl locus generated by homologous recombination in the absence of the Phi locus. [C] . A. J. Lukaszewski, W. Brzezinski International Wheat Genetics Symposium . 2003

机译：在没有Phi轨迹的情况下通过同源重组产生的Gli-Bl基因座的新等位基因。
5. Mutation profiling in colorectal cancer patients with microsatellite instability; High frequency of BRCA2 and EGFR somatic mutations [D] . Deihimi, Safoora. 2016

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6. Mutation rate varies among alleles at a microsatellite locus: Phylogenetic evidence [O] . Li Jin, Claudia Macaubas, Joachim Hallmayer, 1996

机译：微卫星的等位基因之间的突变率不同地点：系统发育证据
7. High mutation rate of a long microsatellite allele in Drosophila melanogaster provides evidence for allele-specific mutation rates [O] . C. Schlotterer, R. Ritter, B. Harr, 1998

机译：德罗罗拉马拉替洛克斯氏菌属长微卫星等位基因的高突变率为等位基因特异性突变率提供了证据

Mutation rate varies among alleles at a microsatellite locus: Phylogenetic evidence

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