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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Chicken interferon consensus sequence-binding protein (ICSBP) and interferon regulatory factor (IRF) 1 genes reveal evolutionary conservation in the IRF gene family.
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Chicken interferon consensus sequence-binding protein (ICSBP) and interferon regulatory factor (IRF) 1 genes reveal evolutionary conservation in the IRF gene family.

机译：鸡干扰素共有序列结合蛋白（ICSBP）和干扰素调节因子（IRF）1基因揭示了IRF基因家族的进化保守性。

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摘要

Members of the IRF family mediate transcriptional responses to interferons (IFNs) and to virus infection. So far, proteins of this family have been studied only among mammalian species. Here we report the isolation of cDNA clones encoding two members of this family from chicken, interferon consensus sequence-binding protein (ICSBP) and IRF-1. The predicted chicken ICSBP and IRF-1 proteins show high levels of sequence similarity to their corresponding human and mouse counterparts. Sequence identities in the putative DNA-binding domains of chicken and human ICSBP and IRF-1 were 97% and 89%, respectively, whereas the C-terminal regions showed identities of 64% and 51%; sequence relationships with mouse ICSBP and IRF-1 are very similar. Chicken ICSBP was found to be expressed in several embryonic tissues, and both chicken IRF-1 and ICSBP were strongly induced in chicken fibroblasts by IFN treatment, supporting the involvement of these factors in IFN-regulated gene expression. The presence of proteins homologous to mammalian IRF family members, together with earlier observations on the occurrence of functionally homologous IFN-responsive elements in chicken and mammalian genes, highlights the conservation of transcriptional mechanisms in the IFN system, a finding that contrasts with the extensive sequence and functional divergence of the IFNs.
机译：IRF家族的成员介导对干扰素（IFN）和病毒感染的转录反应。迄今为止，仅在哺乳动物物种中研究了该家族的蛋白质。在这里，我们报告了从鸡，干扰素共有序列结合蛋白（ICSBP）和IRF-1的编码该家族两个成员的cDNA克隆的分离。预测的鸡ICSBP和IRF-1蛋白与相应的人类和小鼠对应物显示出高水平的序列相似性。鸡和人ICSBP和IRF-1的推定DNA结合域中的序列同一性分别为97％和89％，而C端区域的同一性为64％和51％。与小鼠ICSBP和IRF-1的序列关系非常相似。已发现鸡ICSBP在几种胚胎组织中表达，并且通过IFN处理在鸡成纤维细胞中强烈诱导了鸡IRF-1和ICSBP，从而支持了这些因子参与IFN调控的基因表达。与哺乳动物IRF家族成员同源的蛋白的存在，以及对鸡和哺乳动物基因中功能同源的IFN反应元件的早期观察，突出了IFN系统中转录机制的保守性，这一发现与广泛的序列相反和IFN的功能差异。

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