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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A constant radius of curvature model for the organization of DNA in toroidal condensates.
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A constant radius of curvature model for the organization of DNA in toroidal condensates.

机译：用于环形冷凝物中DNA组织的恒定曲率半径模型。

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摘要

Toroidal DNA condensates have received considerable attention for their possible relationship to the packaging of DNA in viruses and in general as a model of ordered DNA condensation. A spool-like model has primarily been supported for DNA organization within toroids. However, our observations suggest that the actual organization may be considerably different. We present an alternate model in which DNA for a given toroid is organized within a series of equally sized contiguous loops that precess about the toroid axis. A related model for the toroid formation process is also presented. This kinetic model predicts a distribution of toroid sizes for DNA condensed from solution that is in good agreement with experimental data.
机译：环状DNA冷凝物与病毒中DNA的包装之间的可能关系以及通常作为有序DNA冷凝的模型而受到了广泛的关注。线轴样模型主要支持环形结构内的DNA组织。但是，我们的观察表明，实际的组织可能有很大的不同。我们提出了一个替代模型，其中给定环面的DNA在围绕环面轴进动的一系列大小相同的连续环内组织。还介绍了环形形成过程的相关模型。该动力学模型预测从溶液中浓缩的DNA的环形尺寸分布与实验数据非常吻合。

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