Peptide mimicry of the meningococcal group C capsular polysaccharide.

Westerink MA; Giardina PC; Apicella MA; Kieber Emmons T

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Peptide mimicry of the meningococcal group C capsular polysaccharide.

机译：脑膜炎球菌C组荚膜多糖的肽模拟。

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摘要

Sequence analysis of the variable regions of the heavy and light chains of the anti-idiotypic antibody 6F9, which mimics the meningococcal group C capsular polysaccharide (MCP), was performed. The immunogenic site on 6F9 responsible for inducing an anti-MCP antibody response was determined by means of sequence and computer model analysis of these data. Complementarity-determining region 3 (CDR3) was found to be unique in that the sequence tract YRY was exposed on the surface. A synthetic peptide spanning the CDR3 domain was synthesized and complexed to proteosomes (meningococcal group B outer membrane protein). Immunizations of BALB/c mice with the peptide-proteosome complex resulted in a significant anti-MCP antibody response. Immunized mice were protected against infection with a lethal dose of Neisseria meningitidis serogroup C.

机译：对抗独特型抗体6F9的重链和轻链可变区进行了序列分析，该抗体模拟脑膜炎球菌C组荚膜多糖（MCP）。通过对这些数据的序列和计算机模型分析来确定负责诱导抗MCP抗体应答的6F9上的免疫原性位点。发现互补决定区3（CDR3）是独特的，因为序列YRY暴露在表面上。合成了跨越CDR3结构域的合成肽，并与蛋白体（脑膜炎球菌B组外膜蛋白）复合。用肽-蛋白体复合物免疫BALB / c小鼠导致明显的抗MCP抗体反应。用致死剂量的脑膜炎奈瑟氏球菌血清群C保护免疫小鼠免受感染。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1995年第9期|P.4021-4025|共5页
作者
Westerink MA; Giardina PC; Apicella MA; Kieber Emmons T;
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作者单位

Department of Medicine, Medical College of Ohio, Toledo 43699, USA.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Antibodies; Anti-Idiotypic; Immunoglobulin Variable Region; Immunoglobulins; Heavy-Chain; 抗体; 抗独特型; 免疫球蛋白可变区; 免疫球蛋白类; 重链; 免疫球蛋白类; 轻链;

机译：Antibodies;Anti-Idiotypic;Immunoglobulin Variable Region;Immunoglobulins;Heavy-Chain;抗体;抗独特型;免疫球蛋白可变区;免疫球蛋白类;重链;免疫球蛋白类;轻链;

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1. Initial studies of the molecular basis of peptide mimicry of group B streptococcal type III capsular polysaccharide. [J] . Pincus-S H, Lepage-S R, Jung-R F, International reviews of immunology . 2001,第2期

机译：B组链球菌III型荚膜多糖的拟肽分子基础的初步研究。
2. Aspects of antigen mimicry revealed by immunization with a peptide mimetic of Cryptococcus neoformans polysaccharide. [J] . Valadon P, Nussbaum G, Oh J, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1998,第4期

机译：通过用新型隐球菌多糖的肽模拟物免疫揭示了抗原模拟的方面。
3. Expression of concern: "Could the multicomponent meningococcal serogroup B vaccine (4CMenB) control Neisseria meningitidis capsular group X outbreaks in Africa?" and "Bactericidal antibody against a representative epidemiological meningococcal serogroup" [J] . Poland Gregory A. Vaccine . 2020,第35期

机译：关注的表达：“多组分脑膜炎球菌血清疫组B疫苗（4cmenb）控制Neisseria Meningitidis囊组X爆发非洲？” 和“针对代表性流行病学脑膜炎球菌的杀菌抗体血清群”
4. Scaffolded peptides for the mimicry of the discontinuous CD4 binding site of HIV-1 gpl20 [C] . Raimo Franke, Tatjana Hirsch, Jutta Eichler International Peptide Symposium;European Peptide Symposium . 2005

机译：脚手架肽用于敏捷-1 GPL20的不连续CD4结合位点的模拟物
5. Studies of peptide mimicry of the group B streptococcus type III capsular polysaccharide antigen. [D] . Pomwised, Rattanaruji. 2007

机译：B组链球菌III型荚膜多糖抗原的肽模拟研究。
6. Peptide mimicry of the meningococcal group C capsular polysaccharide. [O] . M A Westerink, P C Giardina, M A Apicella, 1995

机译：脑膜炎球菌C组荚膜多糖的肽模拟。
7. Peptide mimicry of the meningococcal group C capsular polysaccharide. [O] . Westerink, M A, Giardina, P C, Apicella, M A, 1995

机译：脑膜炎球菌C组荚膜多糖的肽模拟。

Peptide mimicry of the meningococcal group C capsular polysaccharide.

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