...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Stable loop in the crystal structure of the intercalated four-stranded cytosine-rich metazoan telomere.
【24h】

Stable loop in the crystal structure of the intercalated four-stranded cytosine-rich metazoan telomere.

机译：插层四链富含胞嘧啶的后生端粒的晶体结构中的稳定环。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In most metazoans, the telomeric cytosine-rich strand repeating sequence is d(TAACCC). The crystal structure of this sequence was solved to 1.9-A resolution. Four strands associate via the cytosine-containing parts to form a four-stranded intercalated structure held together by C.C+ hydrogen bonds. The base-paired strands are parallel to each other, and the two duplexes are intercalated into each other in opposite orientations. One TAA end forms a highly stabilized loop with the 5' thymine Hoogsteen-base-paired to the third adenine. The 5' end of this loop is in close proximity to the 3' end of one of the other intercalated cytosine strands. Instead of being entirely in a DNA duplex, this structure suggests the possibility of an alternative conformation for the cytosine-rich telomere strands.
机译：在大多数后生动物中，富端粒胞嘧啶的链重复序列是d（TAACCC）。此序列的晶体结构解析为1.9-A分辨率。四链经由含胞嘧啶的部分缔合以形成通过C.C +氢键保持在一起的四链插入结构。碱基配对的链彼此平行，并且两个双链体以相反的方向彼此插入。一个TAA末端与5'胸腺嘧啶Hoogsteen碱基配对与第三个腺嘌呤形成高度稳定的环。该环的5'端非常接近另一条插入的胞嘧啶链之一的3'端。这种结构并非完全处于DNA双链体中，而是暗示了富含胞嘧啶的端粒链可能具有其他构象。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号