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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Maintenance of protective immunity against malaria by persistent hepatic parasites derived from irradiated sporozoites.
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Maintenance of protective immunity against malaria by persistent hepatic parasites derived from irradiated sporozoites.

机译：通过辐射的子孢子产生的持续性肝寄生虫维持对疟疾的保护性免疫。

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摘要

Immunization of rodents and humans with irradiation-attenuated malaria sporozoites confers preerythrocytic stage-specific protective immunity to challenge infection. This immunity is directed against intrahepatic parasites and involves T cells and interferon gamma, which prevent development of exoerythrocytic stages and subsequent blood infection. The present study was undertaken to determine how protective immunity is achieved after immunization of rodent hosts with irradiated Plasmodium berghei sporozoites. We present evidence that irradiated parasites persist in hepatocytes of rats and mice for up to 6 months after immunization. A relationship between the persistence of parasites and the maintenance of protective immunity was observed. Protective immunity was abrogated in irradiated-sporozoite-immunized rats following the application of chemotherapy to remove preexisting liver parasites. Additionally, protective immunity against sporozoite challenge was established in rats vaccinated with early and late hepatic stages of irradiated parasites. These results show that irradiation-attenuated sporozoites produce persistent intrahepatic stages in vivo necessary for the induction and maintenance of protective immunity.
机译：用辐射减弱的疟疾子孢子对啮齿动物和人类进行免疫，赋予红细胞生成前阶段特异性的保护性免疫力以挑战感染。这种免疫针对肝内寄生虫，涉及T细胞和干扰素γ，可阻止红细胞外阶段的发展和随后的血液感染。进行本研究以确定用辐照的伯氏疟原虫子孢子免疫啮齿动物宿主后如何获得保护性免疫。我们提供的证据表明，免疫后长达6个月的时间，辐照的寄生虫在大鼠和小鼠的肝细胞中持续存在。观察到寄生虫的持久性与维持保护性免疫之间的关系。在应用化学疗法去除先前存在的肝脏寄生虫后，在用辐射子孢子免疫的大鼠中取消了保护性免疫。另外，在接种了早期和晚期肝照射的寄生虫的大鼠中建立了抗子孢子攻击的保护性免疫。这些结果表明，辐射减弱的子孢子在体内产生持续的肝内分期，这对于诱导和维持保护性免疫是必需的。

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