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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery.
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Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery.

机译：桥接移植物和短暂的神经生长因子输注促进长期中枢神经系统神经元的抢救和部分功能的恢复。

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摘要

Grafts of favorable axonal growth substrates were combined with transient nerve growth factor (NGF) infusions to promote morphological and functional recovery in the adult rat brain after lesions of the septohippocampal projection. Long-term septal cholinergic neuronal rescue and partial hippocampal reinnervation were achieved, resulting in partial functional recovery on a simple task assessing habituation but not on a more complex task assessing spatial reference memory. Control animals that received transient NGF infusions without axonal-growth-promoting grafts lacked behavioral recovery but also showed long-term septal neuronal rescue. These findings indicate that (i) partial recovery from central nervous system injury can be induced by both preventing host neuronal loss and promoting host axonal regrowth and (ii) long-term neuronal loss can be prevented with transient NGF infusions.
机译：嫁接有利的轴突生长底物与瞬态神经生长因子（NGF）输注相结合，以促进成年大鼠大脑中海马突突损伤后的形态和功能恢复。实现了长期的间隔胆碱能神经元抢救和部分海马神经支配，从而导致在简单的任务评估习惯性生活中部分恢复功能，但在更复杂的任务评估空间参考记忆中没有实现功能恢复。接受瞬态NGF输注但未促进轴突生长的移植物的对照动物缺乏行为恢复，但也表现出长期的间隔神经元拯救。这些发现表明（i）通过预防宿主神经元丢失和促进宿主轴突再生可以诱导中枢神经系统损伤的部分恢复，以及（ii）瞬时NGF输注可以预防长期神经元丢失。

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