Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.

Sohma Y; Sasano H; Shiga R; Saeki S; Suzuki T; Nagura H; Nose M; Yamamoto T

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Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.

机译：渡边遗传性高脂血症兔动脉粥样硬化病变中浆细胞的积累。

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摘要

By screening a cDNA library constructed from aortic total RNA derived from Watanabe heritable hyperlipidemic (WHHL) rabbits by differential hybridization, we have obtained a cDNA encoding the kappa light chain of immunoglobulin. Northern blot analysis of total RNA prepared from aortas of WHHL and normal rabbits of various ages revealed that this light-chain mRNA accumulates gradually with age in aortas in WHHL rabbits. Northern blotting and in situ hybridization with an antisense oligonucleotide specific to rabbit immunoglobulin gamma heavy-chain mRNA also detected accumulation of this heavy-chain mRNA in advanced lesions of WHHL rabbit aortas. Moreover, immunohistochemical and electron microscopic analyses demonstrated the presence of plasma cells in the atherosclerotic lesions.

机译：通过差异杂交筛选由渡边可遗传性高脂血症（WHHL）兔的主动脉总RNA构建的cDNA文库，我们获得了编码免疫球蛋白κ轻链的cDNA。对WHHL家兔和不同年龄的正常兔的主动脉制备的总RNA的Northern印迹分析表明，该轻链mRNA在WHHL家兔的主动脉中随着年龄的增长而逐渐积累。 Northern印迹和与兔免疫球蛋白γ重链mRNA特异性的反义寡核苷酸的原位杂交也检测到该重链mRNA在WHHL兔主动脉的晚期病变中的积累。此外，免疫组织化学和电子显微镜分析表明动脉粥样硬化病变中浆细胞的存在。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1995年第11期|P.4937-4941|共5页
作者
Sohma Y; Sasano H; Shiga R; Saeki S; Suzuki T; Nagura H; Nose M; Yamamoto T;
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作者单位

Tohoku University Gene Research Center, Tohoku University, Sendai, Japan.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Aorta; Arteriosclerosis; Hyperlipidemia; Immunoglobulins; gamma-Chain; Immunoglobulins; kappa-Chain; 主动脉; 动脉硬化; 高脂血症; 免疫球蛋白类; γ链; 免疫球蛋白类; κ链;

机译：Aorta;Arteriosclerosis;Hyperlipidemia;Immunoglobulins;gamma-Chain;Immunoglobulins;kappa-Chain;主动脉;动脉硬化;高脂血症;免疫球蛋白类;γ链;免疫球蛋白类;κ链;

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1. 99m)Tc-Annexin A5 for noninvasive characterization of atherosclerotic lesions: imaging and histological studies in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits. [J] . Ishino S, Kuge Y, Takai N, European Journal of Nuclear Medicine and Molecular Imaging . 2007,第6期

机译：99m）Tc-Annexin A5用于动脉粥样硬化病变的非侵入性表征：心肌梗死易发性渡边遗传性高脂血症兔的影像学和组织学研究。
2. Effect of fluvastatin sodium on the smooth muscle cells in atherosclerotic plaques. In vivo study using low-density lipoprotein receptor deficient Watanabe heritable hyperlipidemic (WHHL) rabbits. [J] . Shiomi M, Ito T, Tsukada T, Arzneimittel-Forschung: =Drug Research . 1998,第6期

机译：氟伐他汀钠对动脉粥样硬化斑块中平滑肌细胞的影响。使用低密度脂蛋白受体缺陷的渡边遗传性高脂血症（WHHL）兔的体内研究。
3. Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits. [J] . Fukumoto Y, Libby P, Rabkin E, Circulation: An Official Journal of the American Heart Association . 2001,第7期

机译：他汀类药物改变渡边可遗传的高脂血症兔的动脉粥样硬化中的平滑肌细胞积累和胶原蛋白含量。
4. Transplantation of Human Adipose Tissue-Derived Multi-Lineage Progenitor Cells but not Adipose Tissue-Derived Stromal/Stem Cells Reduces Serum Cholesterol in Hyperlipidemic Watanabe Rabbits [C] . Okura H., Soeda M., Morita M., International Congress on Coronary Artery Disease. . 2013

机译：人的移植脂肪组织衍生的多谱系祖细胞但不是脂肪组织衍生的基质/干细胞减少高脂血症Watanabe兔中的血清胆固醇
5. Lipid Accumulation in CD11c-expressing Intimal Myeloid Cells Induces Chemokine Production Required for Leukocyte Recruitment to Early Atherosclerotic Lesions [D] . Siu, Allan. 2013

机译：表达CD11c的内膜骨髓细胞中的脂质蓄积诱导白细胞募集到早期动脉粥样硬化病变所需的趋化因子产生。
6. Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits. [O] . Y Sohma, H Sasano, R Shiga, 1995

机译：渡边遗传性高脂血症兔动脉粥样硬化病变中浆细胞的积累。
7. Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits. [O] . Sohma, Y, Sasano, H, Shiga, R, 1995

机译：渡边遗传性高脂血症兔动脉粥样硬化病变中浆细胞的积累。
8. Imaging of Deep Arterial Lesions by Swept Ultrasound: Research, Development and Evaluation Systems for Noninvasive Detection and Quantification of Atherosclerotic Lesions in Peripheral and Coronary Arteries [R] . Rooney, J. A. , Heyser, R. C. , Le Croissette, D. H. 1987

机译：通过扫描超声成像深部动脉病变：无创检测和外周和冠状动脉粥样硬化病变定量的研究，开发和评估系统

Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.

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