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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A type 1 serine/threonine kinase receptor that can dorsalize mesoderm in Xenopus.
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A type 1 serine/threonine kinase receptor that can dorsalize mesoderm in Xenopus.

机译：1型丝氨酸/苏氨酸激酶受体，可以使非洲爪蟾中胚层背痛。

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摘要

We have cloned a type I serine/threonine kinase receptor, XTrR-I, from Xenopus. XTrR-I (Xenopus transforming growth factor beta-related receptor type I) is expressed in all regions of embryos throughout early development. Overexpression of this receptor does not affect ectoderm or endoderm but dorsalizes the mesoderm such that muscle appears in ventral mesoderm and notochord appears in lateral mesoderm normally fated to become muscle. In addition, overexpression of XTrR-I in UV-treated embryos is able to cause formation of a partial dorsal axis. These results suggest that XTrR-I encodes a receptor which responds in normal development to a transforming growth factor beta-like ligand so as to promote dorsalization. Its function would therefore be to direct mesodermalized tissue into muscle or notochord.
机译：我们已经从非洲爪蟾中克隆了一种I型丝氨酸/苏氨酸激酶受体XTrR-1。 XTrR-1（非洲爪蟾转化生长因子β相关受体I型）在整个早期发育过程中均在胚胎的所有区域表达。该受体的过表达不会影响外胚层或内胚层，但会使中胚层背侧化，从而使肌肉出现在腹侧中胚层中，而脊索肌出现在通常注定会变成肌肉的外侧中胚层中。另外，XTrR-1在紫外线处理过的胚胎中的过表达能够引起部分背轴的形成。这些结果表明，XTrR-1编码一种受体，该受体在正常发育中对转化生长因子β样配体作出反应，从而促进背侧化。因此，其功能是将中胚层组织引导至肌肉或脊索中。

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