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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men.
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Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men.

机译：免疫球蛋白重链/ c-myc重组阳性淋巴细胞克隆在人免疫缺陷病毒感染的同性恋男子的血液中的持久性。

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摘要

We studied blood lymphocytes of human immunodeficiency virus (HIV)-seropositive and -negative homosexual men for the presence of T(8;14) translocations that recombine c-myc and immunoglobulin heavy-chain (IgH) mu/IgH alpha switch regions. Clones with T(8;14) translocations were detected in 10.5% (12/114) of the HIV-positive and in 2.0% of the 99 uninfected patients. The majority of recombinations were found at a single time point only. Four patients, however, harbored multiple (up to four) and persistent (up to 9 years) translocation-positive cell clones. No correlation between the presence of these aberrant lymphocytes and a later lymphoma could be established. The exon 1/intron 1 region of the recombined c-myc was investigated for the presence of point mutations and these were found in the nonpersistent clones. Additional alterations detected in these clones included duplications and a deletion in the c-myc gene. The pattern of base substitution indicates that they were introduced after the translocation event.
机译：我们研究了人类免疫缺陷病毒（HIV）血清阳性和阴性同性恋男性的血液淋巴细胞中是否存在重组c-myc和免疫球蛋白重链（IgH）mu / IgH alpha开关区域的T（8; 14）易位。具有T（8; 14）易位的克隆在HIV阳性的10.5％（12/114）和99％的未感染患者中占2.0％。大多数重组仅在单个时间点发现。但是，四名患者携带多个（最多四个）和持续性（最多9年）易位阳性细胞克隆。这些异常淋巴细胞的存在与后来的淋巴瘤之间没有相关性。研究了重组c-myc的外显子1 /内含子1区是否存在点突变，这些突变在非持久性克隆中发现。在这些克隆中检测到的其他变化包括c-myc基因的重复和缺失。碱基取代的模式表明它们是在易位事件后引入的。

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