CLONING AND EXPRESSION OF TWO BRAIN-SPECIFIC INWARDLY RECTIFYING POTASSIUM CHANNELS

Bredt DS.; Cohen NA.; Guggino WB.; Snyder SH.; Wang TL.

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CLONING AND EXPRESSION OF TWO BRAIN-SPECIFIC INWARDLY RECTIFYING POTASSIUM CHANNELS

机译：两种脑内向性钾通道的克隆和表达

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We have cloned two inwardly rectifying K+ channels that occur selectively in neurons in the brain and are designated BIRK (brain inwardly rectifying K+) channels. BIRK1 mRNA is extremely abundant and is enriched in specific brainstem nuclei, BIRK1 displays a consensus phosphate-binding loop, and expression in Xenopus oocytes has shown that its conductance is inhibited by ATP and adenosine 5'-[gamma-thio] triphosphate. BIRK2 is far less abundant and is selectively localized in telencephalic neurons. BIRK2 has a consensus sequence for cAMP-dependent phosphorylation. [References: 36]

机译：我们已经克隆了两个在大脑神经元中选择性发生的内向整流K +通道，被称为BIRK（脑内向整流K +）通道。 BIRK1 mRNA非常丰富，并且富含特定的脑干核，BIRK1显示出共有的磷酸盐结合环，在非洲爪蟾卵母细胞中的表达表明其电导被ATP和5'-γ-硫代腺苷三磷酸所抑制。 BIRK2远不那么丰富，并且选择性定位在端脑神经元中。 BIRK2具有cAMP依赖性磷酸化的共有序列。 [参考：36]

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《Proceedings of the National Academy of Sciences of the United States of America》 |1995年第15期|p. 6753-6757|共5页
作者
Bredt DS.; Cohen NA.; Guggino WB.; Snyder SH.; Wang TL.;
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作者单位

JOHNS HOPKINS UNIV SCH MED DEPT NEUROSCI 725 N WOLFE ST BALTIMORE MD 21205 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Pancreatic beta-cells; K+-channels; Functional expression; Intracellular atp; Family; Drosophila; Receptor; Genes; Heart; Cdna;

机译：胰腺β细胞;K +通道;功能表达;细胞内ATP;家族;果蝇;受体;基因;心脏;Cdna;

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1. Cloning, expression, and localization of a rat hepatocyte inwardly rectifying potassium channel. [J] . Hill CE, Briggs MM, Liu J, American Journal of Physiology . 2002,第2期

机译：大鼠肝细胞向内整流钾通道的克隆，表达和定位。
2. Cloning and functional expression of the cDNA encoding an inwardly‐rectifying potassium channel expressed in pancreatic β‐cells and in the brain [J] . Auml, mmauml, lauml, FEBS Letters . 1995,第1期

机译：胰腺β细胞和脑中表达的内向整流钾通道的cDNA的克隆和功能表达
3. Cloning, functional expression and mRNA distribution of an inwardly rectifying potassium channel protein [J] . Bauer Christiane K., Corrette Brian J., Falk Torsten, FEBS Letters . 1995,第2期

机译：内向整流钾通道蛋白的克隆，功能表达及mRNA分布
4. Expression and localization of inwardly rectifying potassium channel Kit2.1 in glia cells of native bovine retina [C] . . 2005

机译：内向整流钾通道Kit2.1在天然牛视网膜胶质细胞中的表达和定位
5. Development of Molecular Tools for the Investigation of G protein-gated Inwardly Rectifying Potassium (GIRK) Channels. [D] . Ramos-Hunter, Susan Joanne. 2017

机译：用于研究G蛋白门控的内向整流钾（GIRK）通道的分子工具的开发。
6. Cloning and expression of two brain-specific inwardly rectifying potassium channels. [O] . D S Bredt, T L Wang, N A Cohen, 1995

机译：两个脑特异性向内整流钾通道的克隆和表达。
7. Cloning and expression of two brain-specific inwardly rectifying potassium channels. [O] . Bredt, D S, Wang, T L, Cohen, N A, 1995

机译：两个脑特异性向内整流钾通道的克隆和表达。

CLONING AND EXPRESSION OF TWO BRAIN-SPECIFIC INWARDLY RECTIFYING POTASSIUM CHANNELS

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