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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >ACTIVIN A INHIBITS PAX-6 EXPRESSION AND PERTURBS CELL DIFFERENTIATION IN THE DEVELOPING SPINAL CORD IN VITRO
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ACTIVIN A INHIBITS PAX-6 EXPRESSION AND PERTURBS CELL DIFFERENTIATION IN THE DEVELOPING SPINAL CORD IN VITRO

机译：ACTIVIN A抑制体外发育中的脊髓中PAX-6的表达并扰动细胞分化

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We have developed an in vitro model of the isolated chicken neural plate. Here we demonstrate that even in the absence of notochord, the neural plate rapidly develops a typical dorsoventral patterning. This observation suggests that the ventral cell types are specified or at least predetermined prior to notochord formation and that permissive conditions are sufficient for differentiation of ventral structures. Treatment of the neural plate with activin A extinguishes Pax-6 gene expression, whereas the dorsal markers Pax-3 and Pax-7 are still expressed. The absence of Pax-6 transcripts can be correlated with an impeded differentiation of the motor neurons, whereas the floor plate seems to be enlarged. We propose that the region-specific expression of Pax-6 in the spinal cord is under the control of activin-like molecules. [References: 27]
机译：我们已经开发了分离的鸡神经板的体外模型。在这里，我们证明，即使没有脊索，神经板也会迅速发展出典型的背腹模式。该观察结果表明腹腔细胞类型是在脊索形成之前指定的或至少是预定的，并且允许条件足以分化腹腔结构。用激活素A处理神经板可熄灭Pax-6基因的表达，而背面标记Pax-3和Pax-7仍被表达。 Pax-6转录本的缺失可能与运动神经元分化受阻相关，而底板似乎被放大了。我们提出，Pax-6在脊髓中的区域特异性表达受激活素样分子的控制。 [参考：27]

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