MUTATIONS IN THE MSH3 GENE PREFERENTIALLY LEAD TO DELETIONS WITHIN TRACTS OF SIMPLE REPETITIVE DNA IN SACCHAROMYCES CEREVISIAE

Strand M.; Crouse GF.; Petes TD.; Earley MC.

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MUTATIONS IN THE MSH3 GENE PREFERENTIALLY LEAD TO DELETIONS WITHIN TRACTS OF SIMPLE REPETITIVE DNA IN SACCHAROMYCES CEREVISIAE

机译：在酿酒酵母中，MSH3基因的突变通常导致微量重复DNA缺失。

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Eukaryotic genomes contain tracts of DNA in which a single base or a small number of bases are repeated (microsatellites). Mutations in the yeast DNA mismatch repair genes MSH2 PMS1, and MLH1 increase the frequency of mutations for normal DNA sequences and destabilize microsatellites. Mutations of human homologs of MSH2, PMS1, and MLH1 also cause microsatellite instability and result in certain types of cancer. We find that a mutation in the yeast gene MSH3 that does not substantially affect the rate of spontaneous mutations at several loci increases microsatellite instability about 40-fold, preferentially causing deletions. We suggest that MSH3 has different substrate specificities than the other mismatch repair proteins and that the human MSH3 homolog (MRP1) may be mutated in some tumors with microsatellite instability. [References: 31]

机译：真核生物基因组包含DNA片段，其中重复单个碱基或少量碱基（微卫星）。酵母DNA失配修复基因MSH2 PMS1和MLH1中的突变会增加正常DNA序列的突变频率，并使微卫星不稳定。 MSH2，PMS1和MLH1的人类同源物突变也会引起微卫星不稳定性，并导致某些类型的癌症。我们发现酵母基因MSH3中的一个突变基本上不影响几个位点的自发突变的速率，可使微卫星不稳定性增加约40倍，从而优先引起缺失。我们建议MSH3具有比其他错配修复蛋白不同的底物特异性，并且人MSH3同源物（MRP1）可能在某些具有微卫星不稳定性的肿瘤中发生突变。 [参考：31]

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《Proceedings of the National Academy of Sciences of the United States of America》 |1995年第22期|p. 10418-10421|共4页
作者
Strand M.; Crouse GF.; Petes TD.; Earley MC.;
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作者单位

UNIV N CAROLINA DEPT BIOL CB 3280 CHAPEL HILL NC 27599 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Yeast; Microsatellites; Dna mismatch repair; Mismatch repair; Colorectal-cancer; Yeast; Sequence; Homologs; Cloning;

机译：酵母;微卫星;Dna错配修复;错配修复;结直肠癌;酵母;序列;同源性;克隆;

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2. Ninety-six haploid yeast strains with individual disruptions of open reading frames between YOR097C and YOR192C, constructed for the Saccharomyces Genome Deletion Project, have an additional mutation in the mismatch repair gene MSH3 [J] . Lehner KR, Stone MM, Farber RA, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2007,第3期

机译：为酵母菌基因组缺失项目构建的96个单倍体酵母菌株，其在YOR097C和YOR192C之间的开放阅读框被单独破坏，在错配修复基因MSH3中有一个额外的突变
3. Ninety-Six Haploid Yeast Strains With Individual Disruptions of Open Reading Frames Between YOR097C and YOR192C, Constructed for the Saccharomyces Genome Deletion Project, Have an Additional Mutation in the Mismatch Repair Gene MSH3 [J] . Kevin R. Lehner, Megan M. Stone, Rosann A. Farber, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2007,第3期

机译：为酵母基因组缺失项目构建的九十六个单倍体酵母菌株，其在YOR097C和YOR192C之间的开放阅读框被单独破坏，在错配修复基因MSH3中有一个额外的突变
4. Effect of MIG1 Gene Deletion on Lactose Utilization in Lac~+ Saccharomyces cerevisiae Engineering Strains [C] . Jing Zou, Xuewu Guo, Jian Dong, International conference on applied biotechnology . 2015

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5. C-terminal flap endonuclease (rad27) mutations: Lethal interactions with a DNA ligase I mutation (cdc9-p) and suppression by proliferating cell nuclear antigen (POL30) in Saccharomyces cerevisiae. [D] . Karanja, Kenneth Kimani. 2009

机译：C末端皮瓣内切核酸酶（rad27）突变：与酿酒酵母中DNA连接酶I突变（cdc9-p）的致命相互作用以及通过增殖细胞核抗原（POL30）的抑制作用。
6. Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae. [O] . M Strand, M C Earley, G F Crouse, 1995

机译：MSH3基因中的突变优先导致酿酒酵母中简单重复DNA片段内的缺失。
7. Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae. [O] . Strand, M, Earley, M C, Crouse, G F, 1995

机译：MSH3基因中的突变优先导致酿酒酵母中简单重复DNA片段内的缺失。

MUTATIONS IN THE MSH3 GENE PREFERENTIALLY LEAD TO DELETIONS WITHIN TRACTS OF SIMPLE REPETITIVE DNA IN SACCHAROMYCES CEREVISIAE

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