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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >MYC AND MAX - MOLECULAR EVOLUTION OF A FAMILY OF PROTO-ONCOGENE PRODUCTS AND THEIR DIMERIZATION PARTNER
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MYC AND MAX - MOLECULAR EVOLUTION OF A FAMILY OF PROTO-ONCOGENE PRODUCTS AND THEIR DIMERIZATION PARTNER

机译：原癌基因家族及其二聚体的MYC和最大分子进化

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摘要

The myc gene family encodes a group of transcription factors that regulate cell proliferation and differentiation. These genes are widely studied because of their importance as proto-oncogenes. Phylogenetic analyses are described here for 45 Myc protein sequences representing c-, N-, L-, S-, and B-myc genes. A gene duplication early in vertebrate evolution produced the c-myc lineage and another lineage that later gave rise to the N- and L-myc lineages by another gene duplication. Evolutionary divergence in the myc gene family corresponds closely to the known branching order of the major vertebrate groups. The patterns of sequence evolution are described for five separate highly conserved regions, and these analyses show that differential rates of sequence divergence (= mosaic evolution) have occurred among conserved motifs. Further, the closely related dimerization partner protein Max exhibits significantly less sequence variability than Myc. It is suggested that the reduced variability in max stems from natural selection acting to preserve dimerization capability with products of myc and related genes. [References: 45]
机译：myc基因家族编码一组调节细胞增殖和分化的转录因子。这些基因由于其作为原癌基因的重要性而被广泛研究。系统发生分析在此描述了代表c-，N-，L-，S-和B-myc基因的45个Myc蛋白序列。脊椎动物进化早期的基因复制产生了c-myc谱系，另一种谱系后来又通过另一种基因复制产生了N-和L-myc谱系。 myc基因家族中的进化差异与主要脊椎动物群体的已知分支顺序紧密对应。描述了五个独立的高度保守区域的序列进化模式，这些分析表明，在保守基序中出现了不同的序列分歧速率（=镶嵌进化）。此外，密切相关的二聚化伴侣蛋白Max的序列变异性比Myc小得多。建议最大变异性的降低源自自然选择，该自然选择起着保持myc和相关基因产物的二聚化能力的作用。 [参考：45]

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