Vector-mediated delivery of 125I-labeled beta-amyloid peptide A beta 1-40 through the blood-brain barrier and binding to Alzheimer disease amyloid of the A beta 1-40/vector complex

著录项

• 来源
  《Proceedings of the National Academy of Sciences of the United States of America》 |1995年第22期|p.10227-10231|共5页
• 作者

  Saito Y; Buciak J; Yang J; Pardridge WM;

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• 作者单位

  Department of Medicine, School of Medicine, University of California, Los Angeles 90024, USA.;

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• 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
• 原文格式 PDF
• 正文语种 eng
• 中图分类 自然科学总论;
• 关键词

  Alzheimer Disease metabolism; Amyloid beta-Protein administration dosage metabolism; Amyloid beta-Protein Precursor metabolism; Animals; Antibodies; Monoclonal; Autoradiography; Binding Sites; Biological Transport; Biotin; Blood-Brain Barrier; Brain cytology metabolism; Carotid Artery; Internal; Drug Carriers; Humans; Immunohistochemistry; Infusions; Intra-Arterial; Infusions; Intravenous; Iodine Radioisotopes; Kinetics; Male; Peptide Fragments administration dosage metabolism; Rats; Rats; Sprague-Dawley; Receptors; Transferrin metabolism; Research Support; Non-U.S. Gov't;

  机译：阿尔茨海默氏病代谢;β-淀粉样蛋白的给药与剂量代谢;β-蛋白淀粉样前体的代谢;动物;抗体;单克隆;放射自显影;结合位点;生物转运;生物素;血脑屏障;脑细胞学代谢;颈动脉;内部;药物载体;人类;免疫组化;输液;动脉内;输注;静脉;碘放射性同位素;运动学;男性;肽片段给药与剂量代谢;大鼠;大鼠;Sprague-Dawley;受体;转铁蛋白代谢;研究支持;非美国不会;