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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >CRYSTAL STRUCTURE OF A DNA DECAMER SHOWING A NOVEL PSEUDO FOUR-WAY HELIX-HELIX JUNCTION
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CRYSTAL STRUCTURE OF A DNA DECAMER SHOWING A NOVEL PSEUDO FOUR-WAY HELIX-HELIX JUNCTION

机译：展示新型伪四元螺旋-螺旋连接的DNA十进制编码器的晶体结构

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摘要

The crystal structure of the decanucleotide d(CGCAATTGCG)(2) has been solved by a combination of molecular replacement and heavy-atom procedures and has been refined to an R factor of 20.2% at 2.7 Angstrom. It is not a fully base-paired duplex but has a central core of eight Watson-Crick base pairs flanked by unpaired terminal guanosines and cytosines. These participate in hydrogen-bonding arrangements with adjacent decamer duplexes in the crystal lattice. The unpaired guanosines are bound in the G+C regions of duplex minor grooves. The cytosines have relatively high mobility, even though they are constrained to be in one region where they are involved in base-paired triplets with G-C base pairs. The 5'-AATT sequence in the duplex region has a narrow minor groove, providing further confirmation of the sequence-dependent nature of groove width. [References: 36]
机译：十核苷酸d（CGCAATTGCG）（2）的晶体结构已通过分子置换和重原子过程的组合得以解决，并已在2.7埃下精炼为20.2％的R因子。它不是完全碱基配对的双链体，但具有八对Watson-Crick碱基对的中央核心，两侧是未配对的末端鸟苷和胞嘧啶。这些参与与晶格中相邻的十度双链体的氢键排列。未配对的鸟苷结合在双螺旋小沟的G + C区域。胞嘧啶具有相对较高的迁移率，即使它们被限制在一个区域中，在这些区域中它们与G-C碱基对的碱基配对三胞胎有关。双链体区域中的5'-AATT序列具有狭窄的小凹槽，进一步证实了凹槽宽度与序列相关的性质。 [参考：36]

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