...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >MEIOSIS IN DROSOPHILA - SEEING IS BELIEVING [Review]
【24h】

MEIOSIS IN DROSOPHILA - SEEING IS BELIEVING [Review]

机译：果蝇中的减数分裂-令人信服[评论]

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recently many exciting advances have been achieved in our understanding of Drosophila meiosis due to combined cytological and genetic approaches. Ne cv techniques have permitted the characterization of chromosome position and spindle formation in female meiosis I. The proteins encoded by the nod and ncd genes, two genes known to be needed for the proper partitioning of chromosomes lacking exchange events, have been identified and found to be kinesin-like motors. The effects of mutations in these genes on the spindle and chromosomes, together with the localization of the proteins, have yielded a model for the mechanism of female meiosis I. In male meiosis I, the chromosomal regions responsible for homolog pairing have been resolved to the level of specific DNA sequences. This provides a foundation for elucidating the molecular basis of meiotic pairing. The cytological techniques available in Drosophila also have permitted inroads into the regulation of sister-chromatid segregation. The products of two genes (mei-S332 and ord) essential for sister-chromatid cohesion have been identified recently. Additional advances in understanding Drosophila meiosis are the delineation of a functional centromere by using minichromosome derivatives and the identification of several regulatory genes for the meiotic cell cycle. [References: 59]
机译：最近，由于结合了细胞学和遗传学方法，我们对果蝇减数分裂的理解取得了许多激动人心的进展。新的cv技术已允许鉴定女性减数分裂I中染色体位置和纺锤体形成的特征。由nod和ncd基因编码的蛋白质已被鉴定，发现这两个基因是已知的正确分配缺乏交换事件的染色体所需的两个基因。是驱动蛋白样的马达。这些基因突变对纺锤体和染色体的影响以及蛋白质的定位，为雌性减数分裂I的机理提供了一个模型。在雄性减数分裂I中，负责同源配对的染色体区域已解析为DNA序列的水平。这为阐明减数分裂配对的分子基础提供了基础。果蝇中可用的细胞学技术也允许侵入姐妹染色单体分离的调控。最近已经确定了姐妹染色单体内聚力所必需的两个基因（mei-S332和ord）的产物。了解果蝇减数分裂的其他进展是通过使用微型染色体衍生物描绘功能着丝粒以及鉴定减数分裂细胞周期的几种调控基因。 [参考：59]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号