GENE FOR THE CATALYTIC SUBUNIT OF MOUSE DNA-DEPENDENT PROTEIN KINASE MAPS TO THE SCID LOCUS

Miller RD.; Ozaki JH.; Gell D.; Jackson SP.; Riblet R.; Hogg J.

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GENE FOR THE CATALYTIC SUBUNIT OF MOUSE DNA-DEPENDENT PROTEIN KINASE MAPS TO THE SCID LOCUS

机译：小鼠DNA依赖蛋白激酶激酶催化亚基的基因

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The gene encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) has been proposed recently as a candidate gene for the mouse severe combined immune deficiency (scid) locus, We have used a partial cDNA clone for human DNA-PKcs to map the mouse homologue using a large interspecific backcross panel, We found that the mouse gene for DNA-PKcs does not recombine with scid, consistent with the hypothesis that scid is a mutation in the mouse gene for DNA-PKcs. [References: 45]

机译：最近，有人提出了编码DNA依赖性蛋白激酶（DNA-PKcs）催化亚基的基因，作为小鼠严重联合免疫缺陷（scid）基因座的候选基因。我们使用了部分cDNA克隆用于人DNA-PKcs使用大型种间回交图谱绘制小鼠同源物，我们发现DNA-PKcs的小鼠基因不会与scid重组，这与scid是DNA-PKcs的小鼠基因突变的假设相一致。 [参考：45]

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《Proceedings of the National Academy of Sciences of the United States of America》 |1995年第23期|p. 10792-10795|共4页
作者
Miller RD.; Ozaki JH.; Gell D.; Jackson SP.; Riblet R.; Hogg J.;
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作者单位

UNIV NEW MEXICO DEPT BIOL ALBUQUERQUE NM 87131 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Combined immune-deficiency; Strand break repair; Artificial chromosome library; V(d)j recombination; Ataxia-telangiectasia; Mutation; Yeast; Mice; P53; Antigen;

机译：联合免疫缺陷;断裂修复;人工染色体文库;V（d）j重组;共济失调-毛细血管扩张;突变;酵母;小鼠;P53;抗原;

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专利

1. Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse [J] . Tracy Blunt, David Gell, Margaret Fox Proceedings of the National Academy of Sciences of the United States of America . 1996,第19期

机译：scid小鼠DNA依赖性蛋白激酶催化亚基的羧基末端区域无意义突变的鉴定
2. DNA-Dependent Protein Kinase Catalytic Subunit Is Not Required for Dysfunctional Telomere Fusion and Checkpoint Response in the Telomerase-Deficient Mouse [J] . Richard S. Maser, Kwok-Kin Wong, Erguen Sahin, Molecular and Cellular Biology . 2007,第6期

机译：功能失调的端粒融合和端粒酶缺陷型小鼠中的检查点响应不需要DNA依赖的蛋白激酶催化亚基。
3. H-1, N-15, and C-13 chemical shift assignments of the micelle immersed FAT C-terminal (FATC) domains of the human protein kinases ataxia-telangiectasia mutated (ATM) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) fused to the B1 domain of streptococcal protein G (GB1) [J] . Abd Rahim Munirah S., Sommer Lisa A. M., Wacker Anja, Biomolecular NMR assignments . 2018,第1期

机译：H-1，N-15和C-13化学转移分配的胶束浸渍脂肪C-末端（FATC）结构域的人蛋白激酶突变（ATM）和DNA依赖性蛋白激酶催化亚基（DNA- PKCS）与链球菌蛋白G（GB1）的B1结构域融合
4. Role of phosphorylated Thr-197 in the catalytic subunit of cAMP-dependent protein kinase [C] . Hai-Xiao Jin, Ningbo Institute of Technology, Tian-Xing Wu, 第三届国际分子模拟与信息技术应用学术会议 . 2007

机译：磷酸化的Thr-197在cAMP依赖性蛋白激酶的催化亚基中的作用
5. Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase. [D] . Kazgan, Nevzat. 2010

机译：在AMP激活的蛋白激酶的催化亚基中核输出信号的鉴定。
6. Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus. [O] . R D Miller, J Hogg, J H Ozaki, 1995

机译：小鼠DNA依赖性蛋白激酶的催化亚基的基因定位于scid基因座。
7. Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus. [O] . Miller, R D, Hogg, J, Ozaki, J H, 1995

机译：小鼠DNA依赖性蛋白激酶的催化亚基的基因定位于scid基因座。
8. Solution structure analysis of the conformational changes that occur upon the binding of the protein kinase inhibitor peptide to the catalytic subunit of the cAMP dependent protein kinase [R] . Mitchell, R. D. , Walsh, D. A. , Olah, G. A. , 1994

机译：蛋白激酶抑制剂肽与camp依赖性蛋白激酶催化亚基结合后发生的构象变化的溶液结构分析

GENE FOR THE CATALYTIC SUBUNIT OF MOUSE DNA-DEPENDENT PROTEIN KINASE MAPS TO THE SCID LOCUS

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