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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >CELL DENSITY CONTROL OF STAPHYLOCOCCAL VIRULENCE MEDIATED BY AN OCTAPEPTIDE PHEROMONE
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CELL DENSITY CONTROL OF STAPHYLOCOCCAL VIRULENCE MEDIATED BY AN OCTAPEPTIDE PHEROMONE

机译：八肽信息素介导的葡萄球菌毒力的细胞密度控制

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摘要

Some bacterial pathogens elaborate and secrete virulence factors in response to environmental signals, others in response to a specific host product, and still others in response to no discernible cue. In this study, we have demonstrated that the synthesis of Staphylococcus aureus virulence factors is controlled by a density-sensing system that utilizes an octapeptide produced by the organism itself. The octapeptide activates expression of the agr locus, a global regulator of the virulence response. This response involves the reciprocal regulation of genes encoding surface proteins and those encoding secreted virulence factors. As cells enter the postexponential phase, surface protein genes are repressed by agr and secretory protein genes are subsequently activated. The intracellular agr effector is a regulatory RNA, RNAIII, whose transcription is activated by an agr-encoded signal transduction system for which the octapeptide is the ligand.
机译：一些细菌病原体会根据环境信号来精心设计并分泌毒力因子，其他细菌病原体会针对特定的宿主产物进行响应，而另一些细菌病原体则会对无法识别的线索做出响应。在这项研究中，我们证明了金黄色葡萄球菌毒力因子的合成是由利用生物体自身产生的八肽的密度传感系统控制的。八肽激活了农杆菌基因座的表达，农杆菌基因座是毒力反应的整体调节剂。这种反应涉及编码表面蛋白的基因和编码分泌的毒力因子的基因的相互调节。当细胞进入指数后阶段​​时，表面蛋白基因被agr抑制，随后分泌蛋白基因被激活。细胞内的agr效应子是调控RNA RNAIII，其转录被agr编码的八肽为配体的agr编码信号转导系统激活。

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