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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >CLONING AND COMPARATIVE ANALYSIS OF THE HUMAN PRE-T-CELL RECEPTOR ALPHA-CHAIN GENE
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CLONING AND COMPARATIVE ANALYSIS OF THE HUMAN PRE-T-CELL RECEPTOR ALPHA-CHAIN GENE

机译：人类前T细胞受体α链基因的克隆与比较分析

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摘要

In immature T cells the T-cell receptor (TCR) beta-chain gene is rearranged and expressed before the TCR alpha-chain gene. At this stage TCR beta chain can form disulfide-linked heterodimers with the pre-T-cell receptor alpha chain (pT alpha). Using the recently isolated murine pT alpha cDNA as a probe, we have isolated the human pT alpha cDNA. The complete nucleotide sequence predicts a mature protein of 282 aa consisting of an extracellular immunoglobulin-like domain, a connecting peptide, a transmembrane region, and a long cytoplasmic tail. Amino acid sequence comparison of human pT alpha with the mouse pT alpha molecule reveals high sequence homology in the extracellular as well as the transmembrane region, In contrast, the cytoplasmic region differs in amino acid composition and in length from the murine homologue. The human pT alpha gene is expressed in immature but not mature T cells and is located at the p21.2-p12 region of the short arm of chromosome 6.
机译：在未成熟的T细胞中，T细胞受体（TCR）β链基因在TCRα链基因之前重新排列并表达。在这一阶段，TCRβ链可以与前T细胞受体α链（pT alpha）形成二硫键连接的异二聚体。使用最近分离的鼠pT alpha cDNA作为探针，我们分离了人pT alpha cDNA。完整的核苷酸序列预示着282个氨基酸的成熟蛋白，该蛋白由细胞外免疫球蛋白样结构域，连接肽，跨膜区和较长的细胞质尾巴组成。人pTα与小鼠pTα分子的氨基酸序列比较揭示了细胞外区域和跨膜区域的高序列同源性。相比之下，细胞质区域的氨基酸组成和长度与鼠类同源物不同。人pTα基因在未成熟但未成熟的T细胞中表达，位于6号染色体短臂的p21.2-p12区。

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