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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >SELECTIVE TUMOR KILL OF CEREBRAL GLIOMA BY PHOTODYNAMIC THERAPY USING A BORONATED PORPHYRIN PHOTOSENSITIZER
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SELECTIVE TUMOR KILL OF CEREBRAL GLIOMA BY PHOTODYNAMIC THERAPY USING A BORONATED PORPHYRIN PHOTOSENSITIZER

机译：含硼卟啉光敏剂的光动力疗法对脑胶质瘤的选择性杀伤

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摘要

The prognosis for patients with the high-grade cerebral glioma glioblastoma multiforme is poor. The median survival for primary tumors is <12 months, with most recurring at the site of the original tumor, indicating that a more aggressive local therapy is required to eradicate the unresectable ''nests'' of tumor cells invading into adjacent brain, Two adjuvant therapies with the potential to destroy these cells are porphyrin-sensitized photodynamic therapy (PDT) and boron-sensitized boron neutron capture therapy (BNCT), The ability of a boronated porphyrin, 2,4-((alpha,beta-dihydroxyethyl) deuteroporphyrin Iii tetrakiscarborane carboxylate ester (BOPP), to act as a photosensitizing agent was investigated in vitro with the C6 rat glioma cell line and in vivo with C6 cells grown as an intracerebral tumor after implantation into Wistar rats. These studies determined the doses of BOPP and light required to achieve maximal cell kill in vitro and selective tumor kill in vice, The data show that BOPP is more dose effective in vivo by a factor of 10 than the current clinically used photosensitizer hematoporphyrin derivative and suggest that BOPP may have potential as a dual PDT/BNCT sensitizer.
机译：重型脑胶质母细胞瘤多形的预后不良。原发性肿瘤的中位生存期小于12个月，大多数在原发肿瘤部位复发，这表明需要更积极的局部疗法来根除无法切除的“嵌套”肿瘤细胞侵入相邻大脑，两种佐剂有可能破坏这些细胞的疗法是卟啉敏化光动力学疗法（PDT）和硼敏化硼中子俘获疗法（BNCT），硼化卟啉2,4-（（α，β-二羟乙基）氘卟啉Iii的能力研究人员在C6大鼠神经胶质瘤细胞系中体外研究了四and硼烷羧酸酯（BOPP）作为光敏剂，在植入Wistar大鼠后体内研究了C6细胞作为脑内肿瘤生长的情况，这些研究确定了BOPP和光的剂量需要达到体外最大细胞杀伤力和反之的选择性肿瘤杀伤力。数据显示，BOPP在体内的剂量有效率是当前临床使用的照片的10倍增敏剂血卟啉衍生物，并表明BOPP可能具有双重PDT / BNCT增敏剂的潜力。

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